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Integration of responses to lithium in mussels at different levels of biological complexity.
Chemosphere
January 2025
CBET + Research Group, Department of Zoology and Animal Cell Biology, Faculty of Science and Technology, Research Centre for Experimental Marine Biology and Biotechnology PiE-UPV/EHU, University of the Basque Country UPV/EHU, Areatza z/g, 48620, Plentzia, Bizkaia, Spain. Electronic address:
The increasing use of lithium (Li) in modern technology and medicine has raised up concerns in the scientific community due to the potential impact of this metal on the aquatic environment. Although several effects have been reported in different organisms, there is still scarce information concerning the mechanisms and chronic effects of Li toxicity in marine life. Our main objective is to determine biological effects of sub-lethal concentrations in Mytilus galloprovincialis at different biological organization levels using the biomarker approach.
View Article and Find Full Text PDFThe application of Deep Brain Stimulation in The Syndrome of Irreversible Lithium Effectuated Neurotoxicity.
J Mov Disord
December 2024
Department of Neurology, St. Louis University/SSM Health, St. Louis, Missouri, USA.
Early diagnosis of nonconvulsive status epilepticus due to lithium intoxication using 6-channel electroencephalography.
CJEM
December 2024
Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8553, Japan.
Introduction: Nonconvulsive status epilepticus is a severe complication of lithium intoxication that requires prompt diagnosis and treatment. While conventional electroencephalography (EEG) remains the gold standard for diagnosis for nonconvulsive status epilepticus, its implementation in emergency settings can be challenging and time-consuming. We present a case in which simplified EEG with six electrodes enabled rapid detection and monitoring of nonconvulsive status epilepticus in lithium intoxication in the emergency setting.
View Article and Find Full Text PDFAcute kidney injury induced lithium toxicity with concomitant neuroleptic malignant syndrome.
Biomedicine (Taipei)
September 2024
Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Malaysia.
Article Synopsis
- Lithium is crucial for treating psychiatric disorders but has a narrow therapeutic index, requiring careful monitoring.
- A case study reveals a 50-year-old man with bipolar disorder who developed chronic lithium toxicity and neuroleptic malignant syndrome (NMS) after dehydration from a viral illness, complicating his treatment.
- Recovery involved fluid therapy and supportive care, leading to a successful discharge with a lower potency medication and gradual dose adjustments.
Lithium-induced cognitive dysfunction assessed over 1-year hospitalisation: A case report.
S Afr J Psychiatr
September 2024
Department of Neuropsychiatry, Faculty of Medicine, Kansai Medical University, Osaka, Japan.
Introduction: Lithium-induced neurotoxicity is almost always reversible but can cause irreversible neurological sequelae, namely the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT). As there is no definitive treatment for SILENT, caution is required when administering lithium. Reports on the effect of lithium-effectuated neurotoxicity on cognitive function are limited.
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