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From early methods for DNA diagnostics to genomes and epigenomes at high resolution during four decades - a personal perspective.
Ups J Med Sci
December 2024
Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
In the 1980s, my research career begun with microbial DNA diagnostics at Orion Pharmaceutica in Helsinki, Finland, where I was part of an innovative team that developed novel methods based on the polymerase chain reaction (PCR) and the biotin-avidin interaction. One of our key achievements during this time was the invention of the solid-phase minisequencing method for genotyping single nucleotide polymorphisms (SNPs). In the 1990s, I shifted focus to human genetics, investigating mutations of the 'Finnish disease heritage'.
View Article and Find Full Text PDF[Surgical heritage of academician Bogush L.K. and its influence on modern thoracic and phthisiatric surgery].
Khirurgiia (Mosk)
October 2024
Central Research Institute of Tuberculosis, Moscow, Russia.
The authors discuss the contribution of the outstanding scientist, surgeon, health care organizer and academician Lev K. Bogush in development of original surgeries that saved ten thousands of patients with respiratory diseases. The main periods of phthisiatric surgery are described (no antibacterial drugs and limited technical possibilities of surgical treatment, defining the place of surgery after emergence of specific effective drug treatment, introduction of resection options, drug-resistant forms of disease in population).
View Article and Find Full Text PDFArchaeological Artefact Database of Finland (AADA).
Sci Data
July 2024
Department of Biology, University of Turku, Turku, Finland.
This paper presents the Archaeological Artefact Database of Finland (AADA) of prehistoric (covering period of almost 11,000 years) artefacts in Finland that are categorised by type and are accompanied with photos of the artefacts. The database is intended to contain all typologically classifiable prehistoric artefacts found in Finland and held in Finnish collections. This dataset provides spatio-temporal context for artefacts across different time periods and regions, as it includes approximately 38,000 single artefacts and approximately 10,000 pottery type identifications from the Early Mesolithic to the end of the Iron Age in Finland (c.
View Article and Find Full Text PDFAncient Plasmodium genomes shed light on the history of human malaria.
Nature
July 2024
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Malaria-causing protozoa of the genus Plasmodium have exerted one of the strongest selective pressures on the human genome, and resistance alleles provide biomolecular footprints that outline the historical reach of these species. Nevertheless, debate persists over when and how malaria parasites emerged as human pathogens and spread around the globe. To address these questions, we generated high-coverage ancient mitochondrial and nuclear genome-wide data from P.
View Article and Find Full Text PDFReading tea leaves worldwide: Decoupled drivers of initial litter decomposition mass-loss rate and stabilization.
Ecol Lett
May 2024
Ecology and Biodiversity Group, Institute of Environmental Biology, Utrecht University, Utrecht, The Netherlands.
The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large-scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass-loss rates and stabilization factors of plant-derived carbon, using the Tea Bag Index (TBI).
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