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Murine immune responses to oral BCG immunization in the presence or absence of prior BCG sensitization.
Immunol Cell Biol
February 2010
Centre for Innovation, University of Otago, Dunedin, New Zealand.
Oral delivery of live Mycobacterium bovis BCG in a lipid matrix invokes cell-mediated immune (CMI) responses in mice and consequent protection against pulmonary challenge with virulent mycobacteria. To investigate the influence of prior BCG sensitization on oral vaccine efficacy, we assessed CMI responses and BCG colonization of the alimentary tract lymphatics 5 months after oral vaccination, in both previously naive mice and in mice that had been sensitized to BCG by injection 6 months previously. CMI responses did not differ significantly between mice that received subcutaneous BCG followed by oral BCG and those that received either injected or oral BCG alone.
View Article and Find Full Text PDFThe effect of tuberculin-antigen protein (PPD: purified protein derivatives) on the priming of tumor necrosis factor (TNF) a long time after sensitization with bacillus Calmette-Guérin (BCG) was investigated in mice. Mice were infected intravenously (i.v.
View Article and Find Full Text PDFIt has been postulated that previous exposure to mycobacteria in the environment may be a contributing factor to the variable efficacy of BCG vaccination in protecting against human tuberculosis or leprosy, in different geographical regions. To test this hypothesis mice were given Mycobacterium vaccae in their drinking water for 3 weeks immediately, 27 days, or 54 days before they were injected subcutaneously with BCG. Spleen cells were examined, 50 days after injection of the mice, for ability to proliferate in vitro in response to killed mycobacteria added to the cultures.
View Article and Find Full Text PDFCombined immunostimulation with BCG and double-stranded polyinosinic-polycytidylic acid (poly I . poly C) was more effective than single-modality immunostimulation in suppressing tumor growth in inbred Swiss mice. BCG sensitization followed by administration of poly I .
View Article and Find Full Text PDFEffects of urethan on some functions of blood lymphocytes and peritoneal macrophages (PMs) of rats were studied in in vivo and in vitro experiments. The in vitro lymphokine (LK) producing activity of lymphocytes in the presence of specific antigen was depressed by urethan administered 1-5 days before the BCG sensitization. However, the drug injected after the BCG sensitization was not effective on the LK production.
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