Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cytogenetic Effects in Patients after Computed Tomography Examination.
Life (Basel)
November 2022
Nikiforov Russian Center for Emergency and Radiation Medicine (NRCERM), 194044 Saint-Petersburg, Russia.
Millions of people around the world are exposed to low doses of ionizing radiation from diagnostic computed tomography (CT) scans. Currently available data on the potential cancer risk after CT scans are contradictory and therefore demand further investigations. The aim of the current study was to obtain estimations of genome damage after CT scans in 42 non-cancer patients and to conduct a comparison of the results with 22 control subjects.
View Article and Find Full Text PDFDedifferentiated Liposarcoma: A Comprehensive Historical Review With Proposed Evidence-based Guidelines Regarding a Diagnosis in Need of Further Clarification.
Adv Anat Pathol
November 2021
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH.
Among all sarcoma types, liposarcoma is the most common sarcoma that develops "dedifferentiation." Since its initial description by Dr Harry Evans, the spectrum of what is now acceptably included under the rubric of "dedifferentiated liposarcoma" (DL) has expanded, sometimes supported by cytogenetic and molecular advances. Similarly, the range of morphologic appearances considered to represent the precursor of DL, atypical lipomatous tumor (ALT)/well-differentiated liposarcoma, also has broadened, not uncommonly creating variants with significant, almost indistinguishable, morphologic overlap with occasional forms of DL, especially problematic in small biopsy specimens.
View Article and Find Full Text PDFDevelopment of software and modification of Q-FISH protocol for estimation of individual telomere length in immunopathology.
J Bioinform Comput Biol
April 2017
* Laboratory of the Clinical Immunopathology, Research Institute of Fundamental and Clinical Immunology, 630099, Yadrintsevskaya Street 14, Novosibirsk, Russia.
Telomere length is an important indicator of proliferative cell history and potential. Decreasing telomere length in the cells of an immune system can indicate immune aging in immune-mediated and chronic inflammatory diseases. Quantitative fluorescent in situ hybridization (Q-FISH) of a labeled (CTA[Formula: see text] peptide nucleic acid probe onto fixed metaphase cells followed by digital image microscopy allows the evaluation of telomere length in the arms of individual chromosomes.
View Article and Find Full Text PDFPersistence of Breakage in Specific Chromosome Bands 6 Years after Acute Exposure to Oil.
PLoS One
August 2017
Unitat de Biologia Cel·lular i Genètica Mèdica, Facultat de Medicina, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Background: The identification of breakpoints involved in chromosomal damage could help to detect genes involved in genetic disorders, most notably cancer. Until now, only one published study, carried out by our group, has identified chromosome bands affected by exposure to oil from an oil spill. In that study, which was performed two years after the initial oil exposure in individuals who had participated in clean-up tasks following the wreck of the Prestige, three chromosomal bands (2q21, 3q27, 5q31) were found to be especially prone to breakage.
View Article and Find Full Text PDFFour genes predict high risk of progression from smoldering to symptomatic multiple myeloma (SWOG S0120).
Haematologica
September 2015
Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Multiple myeloma is preceded by an asymptomatic phase, comprising monoclonal gammopathy of uncertain significance and smoldering myeloma. Compared to the former, smoldering myeloma has a higher and non-uniform rate of progression to clinical myeloma, reflecting a subset of patients with higher risk. We evaluated the gene expression profile of smoldering myeloma plasma cells among 105 patients enrolled in a prospective observational trial at our institution, with a view to identifying a high-risk signature.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!