It was shown in dog experiments that intravenous infusion of 30 and 70 U/kg of thrombin leads to the development of a short-term hypercoagulation phase which is replaced by long-term hypocoagulation and marked stimulation of fibrinolysis. An electrocardiogram provides evidence that after the infusion of 70 U/kg of thrombin acute ischemic disorders of coronary circulation develop in the dogs and remain for 3 days. The authors contend that the appearance of high doses of thrombin in the vascular channel is not a physiological reaction.
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