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Clostridial Infections in Cattle: A Comprehensive Review with Emphasis on Current Data Gaps in Brazil.
Animals (Basel)
October 2024
Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal 68740-970, PA, Brazil.
Clostridial infections in cattle are a significant concern for Brazilian livestock. These diseases are caused by various species of , which are known for their ability to produce potent toxins. Botulism in cattle is a serious and often fatal condition caused by the ingestion of neurotoxins produced by .
View Article and Find Full Text PDFProtection efficacy and immunogenicity of Clostridium chauvoei proteins as a subunit blackleg vaccine or an adjuvant for Clostridium perfringens epsilon toxoid.
Toxicon
November 2024
Department of Microbiology, Islamic Azad University, Tehran North Branch, Tehran, Iran.
Potential application of Clostridium chauvoei proteins was studied as a subunit blackleg vaccine or a biological adjuvant for Clostridium perfringens epsilon toxoid vaccine. Extracellular and cell surface proteins were extracted from C. chauvoei culture, and their protective efficacy was evaluated by potency test in guinea pigs.
View Article and Find Full Text PDFProduction of highly soluble and immuno-reactive recombinant flagellin protein of Clostridium chauvoei.
Anaerobe
October 2024
ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, 560064, Karnataka, India. Electronic address:
Objective: Flagellin protein, an integral component of flagella, provides motility to several bacterial species and also acts as a candidate antigen in diagnostics and subunit vaccines. The bulk production of flagellin with retention of all conformational epitopes using recombinant protein technology is of paramount importance in the development of pathogen-specific immuno-assays and vaccines. We describe the production of highly soluble and immuno-reactive rFliA(C) protein of Clostridium chauvoei, a causative agent of blackleg or black quarter (BQ) affecting cattle and small ruminants worldwide.
View Article and Find Full Text PDFBlackleg: A Review of the Agent and Management of the Disease in Brazil.
Animals (Basel)
February 2024
Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal 68740-970, PA, Brazil.
The genus is an important group of pathogenic and nonpathogenic Gram-positive anaerobic bacteria with a sporulation capacity and wide distribution in different environments, including the gastrointestinal tracts of healthy and diseased animals and humans. Among the pathogenic species of the genus, stands out as a histotoxic agent. It causes significant myonecrosis such as blackleg, a disease with high lethality, especially in young cattle, and is responsible for significant livestock losses worldwide.
View Article and Find Full Text PDFEffect of formalin percentage, incubation time and temperature on Clostridium chauvoei culture inactivation and immunogenicity.
Anaerobe
October 2023
Department of Biophysics, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
Objectives: In order to find the optimal inactivation conditions for Clostridium chauvoei culture, different factors were investigated and the immunogenicity of inactivated cultures was studied.
Methods: C. chauvoei was cultured with different formalin percentages (0.
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