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A retrospective study on the association of gastrointestinal symptoms in children with low lactase activity and low activity of other disaccharidases.
BMC Gastroenterol
October 2020
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, USA.
Background: Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum. Previous small studies found no associations between gastrointestinal (GI) symptoms and combined low disaccharidase activity.
View Article and Find Full Text PDFPrevalence of Disaccharidase Deficiency in Adults With Unexplained Gastrointestinal Symptoms.
J Neurogastroenterol Motil
July 2020
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Augusta University, Augusta, GA, USA.
Background/aims: Disaccharidase assay is used for assessing carbohydrate intolerance in children, but its usefulness in adults is not known. The aim of this study is to assess the prevalence of disaccharidase deficiency in patients with unexplained gastrointestinal symptoms.
Methods: A retrospective review of adults with chronic (> 1 year) abdominal symptoms and negative imaging and endoscopy/colonoscopy and who completed bowel symptom questionnaire and duodenal biopsy for lactase, maltase, sucrase, and palatinase was performed.
Clinical and Histopathologic Predictors of Disaccharidase Deficiency in Duodenal Biopsy Specimens.
Am J Clin Pathol
November 2019
Department of Pathology, Microbiology & Immunology, Division of Pediatric Pathology, Vanderbilt University Medical Center, Nashville, TN.
Objectives: Disaccharidase (DS) activity in duodenal biopsy specimens is the gold standard for diagnosing DS deficiency. We investigated strategies to reduce the need for DS testing and whether clinical or histopathologic factors predict DS deficiency.
Methods: A retrospective chart review analyzed 1,678 DS results in children, biopsy indication(s), and duodenal histopathology.
Clinical Characteristics of Disaccharidase Deficiencies Among Children Undergoing Upper Endoscopy.
J Pediatr Gastroenterol Nutr
June 2018
QOL Medical, LLC, Vero Beach, FL.
Objectives: The epidemiology and clinical significance of disaccharidase deficiencies have not been thoroughly characterized. Recent work suggests at least genetic sucrase-isomaltase deficiency is more prevalent than previously believed. Because lactase deficiency (LD) is well described, the present study focuses on the clinical characteristics of children with disaccharidase deficiencies determined by esophagogastroduodenoscopy.
View Article and Find Full Text PDFMetabolic Impacts of Maltase Deficiencies.
J Pediatr Gastroenterol Nutr
June 2018
Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
The mucosal maltase enzymes are characterized by an activity that produces glucose from linear glucose polymers, assayed with the disaccharide maltose. The related enzyme isomaltase produces glucose from branched glucose polymers, assayed with palatinose. Maltase and isomaltase activities are part of the 4 disaccharidases assayed from clinical duodenal biopsy homogenates.
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