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Dynamic regulation of ion transport through a bis(1,3-propanediol)-based channel allosteric azobenzene photoswitching.
Nanoscale
December 2024
Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr Homi Bhabha Road, Pashan, Pune 411008, Maharashtra, India.
The transportation of ions across cell membranes is vital in biological functions and is frequently controlled by external triggers like light, ligands, and voltage. Synthetic ion transport systems, particularly those featuring gating mechanisms, have attracted considerable interest. In this research, we engineered self-assembled barrel rosette ion channels using a photoresponsive azobenzene integrated at an allosteric site.
View Article and Find Full Text PDFProton-free induction decay MRSI at 7 T in the human brain using an egg-shaped modified rosette K-space trajectory.
Magn Reson Med
November 2024
High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria.
Purpose: Proton (H)-MRSI via spatial-spectral encoding poses high demands on gradient hardware at ultra-high fields and high-resolutions. Rosette trajectories help alleviate these problems, but at reduced SNR-efficiency because of their k-space densities not matching any desired k-space filter. We propose modified rosette trajectories, which more closely match a Hamming filter, and thereby improve SNR performance while still staying within gradient hardware limitations and without prolonging scan time.
View Article and Find Full Text PDFCLAVATA3 Signaling Buffers Arabidopsis Shoot Apical Meristem Activity in Response to Photoperiod.
Int J Mol Sci
August 2024
Plant Gene Expression Center, United States Department of Agriculture-Agricultural Research Service, Albany, CA 94710, USA.
Land plants grow throughout their life cycle via the continuous activity of stem cell reservoirs contained within their apical meristems. The shoot apical meristem (SAM) of Arabidopsis and other land plants responds to a variety of environmental cues, yet little is known about the response of meristems to seasonal changes in day length, or photoperiod. Here, the vegetative and reproductive growth of Arabidopsis wild-type and plants in different photoperiod conditions was analyzed.
View Article and Find Full Text PDFCNS Embryonal Tumor with PLAGL Amplification, a New Tumor Type in Children and Adolescents: Insights from a Comprehensive MRI Analysis.
AJNR Am J Neuroradiol
September 2024
From the Inst. of Neuroradiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany (T.A.); Dept. of Neuroradiology, University Hospital Augsburg, Germany (B.B.); Neuroradiological Reference Center for the pediatric brain tumor (HIT) studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany (B.B.); Service de Neurochirurgie B, CHU de Bordeaux, University of Bourdeaux, France (E.J.); Univ. Bordeaux, Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France (E.J.); Institut de Pathologie Multisite-Site Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France (F.T., M.D., V.A.); Aix- Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France (FB.D.); Dept. of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (G.E.); Dept. of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (H.J.); Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (H.J.); Dept. of Pediatric Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany (K.E.); Murdoch Children's Research Inst., The Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia (L.LE); Children's Cancer Centre, The Royal Children's Hospital, Flemington Road, Parkville, Victoria, 3052, Australia (L.LE); Dept. of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia (L.LE); Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden (N.P.); Dept. of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (N.P.); Dept. of Pediatric Oncology and Hematology, Skåne University Hospital, Lund University, Lund, Sweden (Ø.I); Dept. of Pediatrics, Pediatric Hematology and Oncology Ward, Kuopio University Hospital and Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (P.J.); Dept. of Clinical Pathology, Kuopio University Hospital and Unit of Pathology, Inst. of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (R.T.); Dept. of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (R.RE.); Dept. of Hematology-Oncology, Valley Children's Hospital, Madera, CA, USA (S.D.); Rare Cancers Genomics Team, Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France (S-O.A.); Inst. of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (W.A.K.); Dept. of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic (Z.J.); Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany (J.D.T.W., K.M.K.); Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany (J.D.T.W., K.M.K.); National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany (J.D.T.W., K.M.K.); Dept. of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Inst. of Health, Berlin, Germany (V.H.K.); Dept. of Paediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (V.H.K.); (European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group.
Background And Purpose: CNS embryonal tumor with amplification (ET, PLAGL) is a newly identified, highly malignant pediatric tumor. Systematic MRI descriptions of ET, PLAGL are currently lacking.
Materials And Methods: MRI data from 19 treatment-naïve patients with confirmed ET, PLAGL were analyzed.
Prey size and ecological separation in spinosaurid theropods based on heterodonty and rostrum shape.
Anat Rec (Hoboken)
August 2024
School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Members of the dinosaur clade Spinosauridae had numerous traits attributed to feeding in or around water, and their feeding apparatus has often been considered analogous to modern crocodylians. Here we quantify the craniodental morphology of Spinosauridae and compare it to modern Crocodylia. We measured from spinosaurid and crocodylian skeletal material the area of alveoli as a proxy for tooth size to determine size-heterodonty.
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