The mechanism of the stimulant effect of methylcobalamine on the growth of mouse adenocarcinoma 755 was studied. More rapid growth of adenocarcinoma 755 under the cobalamine coentzyme effect is consequent on an increased proliferative pool with the stable parameters of the mitotic cycle and minimal death of tumour cells. Apparently, inhibition of DNA synthesis in the greater S-phase cell subpopulation potentiated the antitumour effect of methotrexate combined with methylcobalamine.
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