Administration of cycloheximide to rats does not change the activity of acid and alkaline RNAases in the cytoplasm of hepatocytes. At the same time cycloheximide-induced inhibition of protein synthesis leads to a fall in the activity of RNAase of microsomes and membrane-bound polyribosomes. The activity of RNAase of free polyribosomes of hepatocytes rises considerably under the action of cycloheximide.
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