To determine the status of the population's immunity to diphtheria, the Schick test was performed on 489 and the diphtheria antitoxin level determined in 404 hospital patients, all residents of Helsinki. A low ("unprotective", less than 0.01 IU/ml) antitoxin level was found in not more than 5% among persons under 20. The highest percentage, 48%, was found in the 50--59 years age group. A low antitoxin level was more common among women than men in those over 40 years of age. Taking into consideration the age structure of the population of Helsinki in 1975, 23% of the population had an antitoxin level less than 0.01 IU/ml. The percentage of Schick-positives among different age groups was almost the same as the percentage of low antitoxin levels. Of 100 serum samples from military recruits coming from different regions of the country, 15% had an antitoxin level below 0.01 IU/ml.
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http://dx.doi.org/10.3109/inf.1980.12.issue-1.07 | DOI Listing |
Microorganisms
January 2025
Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China.
The adhesion between dibenzofuran (DF) and degrading bacteria is the first step of DF biodegradation and affects the efficient degradation of DF. However, their efficient adhesion mechanism at the molecular level remains unclear. Therefore, this study first examined the adhesive behaviors and molecular mechanisms of sp.
View Article and Find Full Text PDFToxins (Basel)
December 2024
Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes of envenoming and developing therapeutic approaches to the treatment of envenoming, especially regarding the timing and optimal dosage of antivenom administration. (Eastern Russell's viper) envenoming causes systemic coagulopathy and severe hemorrhage including acute kidney injury. These toxic outcomes can be diminished by the administration of high quantities of Russell's viper antivenom.
View Article and Find Full Text PDFInt J Public Health
January 2025
School of Public Health, Hainan Medical University, Haikou, Hainan Province, China.
Objectives: To analyze the spatial accessibility of antivenom immunizing agents equipped hospitals in Hainan Province.
Methods: This paper analyzes the spatial accessibility of medical institutions equipped with different types of snake antivenom using network analysis and two-step mobile search method, and evaluates the service level and spatial accessibility of medical institutions equipped with different types of antivenom immunizing agents in Hainan Province from the perspectives of both supply and demand.
Results: The number of people in Hainan Province who need to spend more than 1 h to reach an antivenom, antivenom, antivenom, antivenom equipped hospital, and equipped with antivenom for all species of snakes in the country is approximately 856,000, 231,300, 3,071,000, 2,666,000 and 4,721,000 people, respectively.
Drug Des Devel Ther
January 2025
Department of Hepatobiliary Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People's Republic of China.
Introduction: Oxidative stress is an important cause of acetaminophen (APAP)-induced liver injury (AILI). Sakuranetin (Sak) is an antitoxin from the cherry flavonoid plant with good antioxidant effects. However, whether sakuranetine has a protective effect on APAP-induced liver injury is not clear.
View Article and Find Full Text PDFInt J Infect Dis
January 2025
Koç University-Isbank Center for Infectious Diseases, Istanbul, Turkey; Department of Infectious Diseases, Koç University School of Medicine, Istanbul, Turkey. Electronic address:
Objectives: This study identifies key risk factors for fatality among adult tetanus patients, assesses the impact of vaccination status and antibody levels on disease severity and outcomes in tetanus cases. Despite widespread vaccination, fatality rates remain high due to diagnostic and management challenges.
Design/methods: A meta-analysis of 182 tetanus cases from 36 countries, published since 1990, was conducted.
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