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Impact of hemoadsorption with CytoSorb® on meropenem and piperacillin exposure in critically ill patients in a post-CKRT setup: a single-center, retrospective data analysis.
Intensive Care Med Exp
January 2025
Freie Universität Berlin and Humboldt-Universität Zu Berlin, Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Purpose: CytoSorb® (CS) adsorbent is a hemoadsorption filter for extracorporeal blood purification often integrated into continuous kidney replacement therapy (CKRT). It is primarily used in critically ill patients with sepsis and related conditions, including cytokine storms and systemic inflammatory responses. Up to now, there is no evidence nor recommendation for the use of CS filters in sepsis (22).
View Article and Find Full Text PDFA systematic review of plastic recycling: technology, environmental impact and economic evaluation.
Waste Manag Res
January 2025
Bohai Rim Energy Research Institute, Northeast Petroleum University, Daqing, Heilongjiang, China.
In this systematic review, advancements in plastic recycling technologies, including mechanical, thermolysis, chemical and biological methods, are examined. Comparisons among recycling technologies have identified current research trends, including a focus on pretreatment technologies for waste materials and the development of new organic chemistry or biological techniques that enable recycling with minimal energy consumption. Existing environmental and economic studies are also compared.
View Article and Find Full Text PDFThe promise of AI in healthcare: transforming communication and decision-making for patients.
J Commun Healthc
January 2025
Venditti Consulting, LLC, Westport, CT, United States.
By addressing communication gaps, the integration of AI tools in healthcare has a greater ability to improve decision-making and to empower patients with more control over their health. Current systems for navigating healthcare - such as finding providers or understanding costs - are fragmented and cumbersome, often leaving patients frustrated and uninformed. An AI Healthcare Assistant App, leveraging advances in health IT interoperability, price transparency, and user-centred design, could simplify these processes.
View Article and Find Full Text PDFExploring the purpose and stages of patient and public involvement and engagement (PPIE) in audiology research: a case study approach.
Res Involv Engagem
January 2025
Patient Researcher and PPI Lead, College of Health and Life Sciences, Aston University, Birmingham, UK.
Background: Patient and Public Involvement and Engagement (PPIE) has become an integral component of contemporary audiology research. It aims to capture diverse views and experiences, essential for evaluating the long-term impact of technological advancements and care models on individuals. Traditional inclusion methods, such as focus groups, may exclude individuals with additional needs or communication difficulties, necessitating the development of more inclusive approaches.
View Article and Find Full Text PDFMeta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer.
Genome Med
January 2025
Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
Background: Despite extensive analysis, the dynamic changes in prostate epithelial cell states during tissue homeostasis as well as tumor initiation and progression have been poorly characterized. However, recent advances in single-cell RNA-sequencing (scRNA-seq) technology have greatly facilitated studies of cell states and plasticity in tissue maintenance and cancer, including in the prostate.
Methods: We have performed meta-analyses of new and previously published scRNA-seq datasets for mouse and human prostate tissues to identify and compare cell populations across datasets in a uniform manner.
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