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Perceiving inter-leg speed differences while walking on a split-belt treadmill.
Sci Rep
January 2025
Cognitive Systems Lab, Institute of Physics, Chemnitz University of Technology, Reichenhainer Str. 70, 09126, Chemnitz, Germany.
Walking is one of the most common forms of self-motion in humans. Most humans can walk effortlessly over flat uniform terrain, but also a variety of more challenging surfaces, as they adjust their gait to the demands of the terrain. In this, they rely in part on the perception of their own gait and of when it needs to be adjusted.
View Article and Find Full Text PDFUnlabelled: "Single Model initial-condition Large Ensembles" (SMILEs) conducted with Earth system models have transformed our ability to quantify internal climate variability and forced climate change at local and regional scales. An important consideration in their experimental design is the choice of initialization procedure as this influences the duration of initial-condition memory, with implications for interpreting the temporal evolution of both the ensemble-mean and ensemble-spread. Here we leverage the strategic design of the 100-member Community Earth System Model version 2 (CESM2) SMILE to investigate the dependence of ensemble spread on the method of initialization (micro- vs.
View Article and Find Full Text PDFmissense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization.
bioRxiv
December 2024
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States.
Pathogenic coding mutations are prevalent in human neuronal transcription factors (TFs) but how they disrupt development is poorly understood. Lmx1b is a master transcriptional regulator of postmitotic neurons that give rise to mature serotonin (5-HT) neurons; over two hundred pathogenic heterozygous mutations have been discovered in human yet their impact on brain development has not been investigated. Here, we developed mouse models with different DNA-binding missense mutations.
View Article and Find Full Text PDFIdentifying the Mechanism of Interaction Between Soil Moisture State and Summertime MCS Initiations in Weakly Forced Synoptic Environments Using Convective-Permitting Simulations.
J Geophys Res Atmos
December 2024
Climate Prediction Center National Oceanic and Atmospheric Administration College Park MD USA.
This work aims to identify a mechanism of interaction between soil moisture (SM) state and the incidence of weakly forced synoptic scale MCS events during boreal summer by performing a sensitivity study using the Weather Research and Forecasting (WRF) model over the US Great Plains. A uniformly dry SM patch at a 5° × 5° scale is centered at the point of a documented MCS initiation to observe spatiotemporal changes of the simulated MCS events, totaling 97 cases between 2004 and 2017. A storm-centered composite analysis of SM at the location of simulated MCS events depicted SM heterogeneity [O(100) km] structured as significantly drier soils to the southwest (SW) transitioning to wetter soils northeast (NE) of the mean simulated initiation.
View Article and Find Full Text PDFThe integration of the continous-variable quantum key distribution(CVQKD) system is an important technical route with great potential value for constructing high-performance and low-cost CVQKD system. In all previous CVQKD studies, the quantum efficiency of the detector can be calibrated in advance and is considered to remain unchanged. But when the size of the system shrinks to the on-chip level, especially in the premise of non-uniform waveguide, heavy doping and other factors, effects such as free carrier absorption and scattering loss will become prominent, which will directly cause carriers undergo violent migration due to the tiny jitter of the local oscillator and further lead to dynamical variation of quantum efficiency of detection.
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