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HYDROGEN SULFIDE AND CYSTATHIONINE γ-LYASE LEVELS FOR PATIENTS WITH PARKINSON'S DISEASE.
Georgian Med News
November 2024
2Department of Chemistry, College of Science, University of Mosul, Iraq.
Parkinson's disease (PD) is a complicated neurodegenerative disease that is the most prevalent severe movement disorder worldwide. The research includes studying the levels of hydrogen sulphide (H2S) and cystathionine γ-lyase (CSE) with some biochemical parameters in the serum of patients with PD in Mosul City (Iraq), which include Serotonin (SERT), dopamine (DA), sphingomyelin (SM), vitamin B12, Acetylcholine esterase (AChE), monoamine oxidase (MAO), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT). Samples reached (100), which included: (40) for the Parkinson's patients group, and (60) for the control group.
View Article and Find Full Text PDFCombined Effects of Arsenic and Bisphenol-A on Locomotor Activity and Oxidative Stress Mediated Neurotoxicity in Mice.
Biol Trace Elem Res
January 2025
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh.
Bisphenol A (BPA) is a monomer of plastic that can leach into water from scratched containers when used for an extended period. Arsenic (As) is an environmental toxicant, and people are exposed to both arsenic and BPA through drinking water and through scratched plastic containers used in contaminated areas. However, the combined effects of As and BPA on locomotor performance and neurobehavioral changes are yet to be investigated.
View Article and Find Full Text PDFEffects of walnut kernel pellicle on the composition and properties of enzymatic hydrolysates of walnut meal by peptidomics and bioinformatics.
J Food Sci
January 2025
Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of Chemistry and Materials Science, National Demonstration Center for Experimental Chemistry Education, Northwest University, Xi'an, China.
The purpose of this article is to investigate the effects of walnut (Juglans regia L.) kernel pellicle on the composition and properties of enzymatic hydrolysis products of walnut meal using peptidomics and bioinformatics. In this study, a total of 3423 peptide sequences were identified in peeled walnut protein hydrolysates (PWPH) and unpeeled walnut protein hydrolysates (UWPH).
View Article and Find Full Text PDFIntegrating epigenetic modification and stem cell therapy strategies: A novel approach for advancing Alzheimer's disease treatment - A literature review.
Narra J
December 2024
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Alzheimer's disease (AD) is the most frequent form of dementia and represents an increasing global burden, particularly in countries like Indonesia, where the population has begun to age significantly. Current medications, including cholinesterase inhibitors and NMDA receptor antagonists, have modest effects on clinical symptoms in the early to middle stages, but there is no curative treatment available so far despite progress. Activating or repressing epigenetic modifications, including DNA methylation, histone modification and microRNA regulation, appears to play an important role in AD development.
View Article and Find Full Text PDFBeyond the virus: ecotoxicological and reproductive impacts of SARS-CoV-2 lysate protein in C57Bl/6j female mice.
Environ Sci Pollut Res Int
January 2025
Post-Graduation Program in Ecology, Conservation, and Biodiversity, Federal University of Uberlândia, Uberlândia, MG, 38408144, Brazil.
Since the establishment of the COVID-19 pandemic, a range of studies have been developed to understand the pathogenesis of SARS-CoV-2 infection, vaccine development, and therapeutic testing. However, the possible impacts that these viruses can have on non-target organisms have been explored little, and our knowledge of the consequences of the COVID-19 pandemic for biota is still very limited. Thus, the current study aimed to address this knowledge gap by evaluating the possible impacts of oral exposure of C57Bl/6 J female mice to SARS-CoV-2 lysate protein (at 20 µg/L) for 30 days, using multiple methods, including behavioral assessments, biochemical analyses, and histopathological examinations.
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