Estrogen excretion was studied by fractions in the urine of 10 healthy men and in 11 men suffering from fluorosis before and after the chorionic gonadotropin (CG) load. The response to the CG administration was expressed in increased urinary estrogens excretion in the healthy men and in the patients with fluorosis; the hyperexcretion intensity depended on the dose of the hormone administered. In comparison with healthy men, patients with fluorosis displayed specific temporary shifts in the maximal estrogen excretion peaks, and also a significant increase in estriol concentration in the urine. A conclusion was drawn that changes in the estrogen concentration in the urine of patients with fluorosis were connected with disturbed metabolism of these steroids, and not with elevation of their production in the testes.
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