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Immune cell changes in infection-induced glandular epithelial cell damage of the gastric mucosa.
Ann Med
December 2024
Department of Pathology, The Fourth People's Hospital of Longgang District, Shenzhen, Shenzhen, China.
Objective: The purpose of this study was to investigate the relationship between () infection-induced changes in gastric mucosal immune cells and glandular epithelial cell damage and the histopathological characteristics of these changes.
Methods: We performed a detailed histomorphometry and immunohistochemical analysis of a total of 1635 -infected gastric mucosal specimens.
Results: Stage-wise features were as follows: Early stage of infection: was colonized in the mucous layer, and very few neutrophils were visible in the layer.
Imaging Intranuclear Actin Rods in Live Heat Stressed Drosophila Embryos.
J Vis Exp
May 2020
Integrative Molecular and Biomedical Sciences, Baylor College of Medicine; Department of Cell and Molecular Biology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine;
The purpose of this protocol is to visualize intranuclear actin rods that assemble in live Drosophila melanogaster embryos following heat stress. Actin rods are a hallmark of a conserved, inducible Actin Stress Response (ASR) that accompanies human pathologies, including neurodegenerative disease. Previously, we showed that the ASR contributes to morphogenesis failures and reduced viability of developing embryos.
View Article and Find Full Text PDFAntibodies to H2a and H2b histones from the sera of HIV-infected patients catalyze site-specific degradation of these histones.
Mol Biosyst
June 2017
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrentiev Ave. 8, 630090, Russia.
Article Synopsis
- Histones are essential for chromatin remodeling and gene expression, and their release into the extracellular space can trigger inflammatory responses and toxicity in animals.
- Some HIV-infected patients produce unique autoantibodies (abzymes) that can specifically cleave histones, unlike standard proteases which target a broader range of proteins.
- Using mass spectrometry, researchers identified specific cleavage sites on histones H2a and H2b, which are concentrated at critical interaction points within nucleosomes, revealing insights into their functional dynamics in disease conditions.
The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation.
J Virol
February 2017
Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
Unlabelled: PML nuclear bodies (NBs) are accumulations of cellular proteins embedded in a scaffold-like structure built by SUMO-modified PML/TRIM19. PML and other NB proteins act as cellular restriction factors against human cytomegalovirus (HCMV); however, this intrinsic defense is counteracted by the immediate early protein 1 (IE1) of HCMV. IE1 directly interacts with the PML coiled-coil domain via its globular core region and disrupts NB foci by inducing a loss of PML SUMOylation.
View Article and Find Full Text PDFAntibodies to H1 histone from the sera of HIV-infected patients recognize and catalyze site-specific degradation of this histone.
J Mol Recognit
March 2017
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Lavrentiev Ave. 8, 630090, Novosibirsk, Russia.
Article Synopsis
- Histones play crucial roles in gene regulation and chromatin structure, but when released into the body, they can trigger inflammation and toxicity.
- In HIV-infected patients, unique IgG antibodies with enzymatic activity were found to specifically target and break down histones, differing from regular proteases that act on a broader range of proteins.
- Detailed analysis revealed specific cleavage sites on the H1 histone, with some regions being resistant to these IgG antibodies, suggesting that the antibodies could be significant in the pathology of HIV and potentially other diseases.
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