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Intestinal Cells-on-Chip for Permeability Studies.
Micromachines (Basel)
November 2024
Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.
Background: To accurately measure permeability of compounds in the intestine, there is a need for preclinical in vitro models that accurately represent the specificity, integrity and complexity of the human small intestinal barrier. Intestine-on-chip systems hold considerable promise as testing platforms, but several characteristics still require optimization and further development.
Methods: An established intestine-on-chip model for tissue explants was adopted for intestinal cell monolayer culture.
Cortical Laminar Bone Membrane: Transforming Regenerative Approaches in Dentistry.
Cureus
December 2024
Oral Pathology and Microbiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND.
Cortical laminar bone membrane (CLBM) is well known for its extraordinary mechanical properties, biocompatibility, and osteoconductive potential, and thus, it has been revealed as a revolutionary biomaterial in periodontal and alveolar bone regeneration. CLBM offers a superior alternative to traditional barrier membranes used in guided bone regeneration (GBR) and guided tissue regeneration (GTR). CLBM represents a significant advancement in managing complex defects by overcoming common limitations such as premature degradation and inadequate soft tissue support.
View Article and Find Full Text PDFThree distinct gamma oscillatory networks within cortical columns in macaque monkeys' area V1.
Front Neural Circuits
December 2024
Cognitive Neurophysiology, Brain Research Institute, University of Bremen, Bremen, Germany.
Introduction: A fundamental property of the neocortex is its columnar organization in many species. Generally, neurons of the same column share stimulus preferences and have strong anatomical connections across layers. These features suggest that neurons within a column operate as one unified network.
View Article and Find Full Text PDFSpall: accurate and robust unveiling cellular landscapes from spatially resolved transcriptomics data using a decomposition network.
BMC Bioinformatics
December 2024
Center of Intelligent Medicine, School of Control Science and Engineering, Shandong University, Jinan, 250061, Shandong, China.
Recent developments in spatially resolved transcriptomics (SRT) enable the characterization of spatial structures for different tissues. Many decomposition methods have been proposed to depict the cellular distribution within tissues. However, existing computational methods struggle to balance spatial continuity in cell distribution with the preservation of cell-specific characteristics.
View Article and Find Full Text PDFInitial regional cytoarchitectonic differences in dorsal and orbitobasal human developing frontal cortex revealed by spatial transcriptomics.
Brain Struct Funct
December 2024
School of Medicine, Croatian Institute for Brain Research, University of Zagreb, Zagreb, Croatia.
Early development of the human fetal cerebral cortex involves a set of precisely coordinated molecular processes that remains rather underexplored. Previous studies indicate that the laminar identity and the molecular specification of cortical neurons driven by genetic programming, as well as associated histogenetic events begin during early fetal development. Our recent study discovered unique regional cytoarchitectonic features in the developing human frontal lobe, including migratory waves of postmitotic neurons in the dorsal frontal cortex and the "double plate" feature in orbitobasal cortex (Kopić et al.
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