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Assessing the marginal seal of bioactive restorative materials in class II cavities with a bacterial penetration model.
Dent Mater
March 2025
Department of Conservative Dentistry and Periodontology, LMU University Hospital, LMU Munich, Goethestrasse 70, Munich 80336, Germany.
Objectives: The aim of this study was to examine the marginal seal of novel bioactive restorative materials and the material-related properties associated with bacterial microleakage.
Methods: Class II cavities prepared into human extracted teeth were restored with: Venus Diamond (VD) + selective enamel etching (SEE)/self-etching universal adhesive (SEA), ACTIVA BioACTIVE RESTORATIVE (AB) + SEE/SEA, Cention Forte (CF) + Cention Primer, Ketac Universal Aplicap (KU), EQUIA Forte HT (EF) and Surefil One (SO) and exposed to a cariogenic multi-species bacterial suspension for 7 days. Bacterial microleakage was visualized with a modified gram staining protocol and bacterial penetration depths were microscopically determined after sectioning the teeth.
Cone Rod Homeobox (): literature review and new insights.
Ophthalmic Genet
March 2025
Ophthalmic Genetics & Visual Function Branch, National Eye Institute, Bethesda, Virginia, USA.
The development of the neural retina requires a complex, spatiotemporally regulated network of gene expression. Here we review the role of the cone rod homeobox () transcription factor in specification and differentiation of retinal photoreceptors and its function in inherited retinal diseases such as cone-rod dystrophy (CoRD), dominant retinitis pigmentosa (RP), and Leber's congenital amaurosis (LCA). We delineate the findings of animal models and, more recently, human retinal organoids in elucidating molecular mechanisms of CRX activity and the pathogenesis of inherited photoreceptor degenerations.
View Article and Find Full Text PDFAssociation Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm.
J Am Coll Cardiol
March 2025
Ciccarone Center for Prevention of Cardiovascular Disease, Johns Hopkins Medicine, Baltimore, Maryland, USA; American Heart Association Tobacco Regulation and Addiction Center, Dallas, Texas, USA. Electronic address:
Background: Cigarette smoking is a strong risk factor for cardiovascular harm.
Objectives: The study sought to explore the detailed relationships between smoking intensity, pack-years, and time since cessation with inflammation, thrombosis, and subclinical atherosclerosis markers of cardiovascular harm.
Methods: We included 182,364 participants (mean age 58.
In situ global mapping of protein perturbations via protein abundance and conformation analysis.
Anal Chim Acta
May 2025
State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 639 Longmian Dadao, Nanjing, 211198, China. Electronic address:
Background: Traditional studies of protein responses to external stimuli primarily focus on changes in protein abundance, often overlooking the critical role of protein conformational alterations. To address this gap, we developed Protein Abundance and Conformation Analysis (PACA), an integrative method that quantifies both protein abundance and conformational changes. PACA combines conventional quantitative proteomics for abundance measurements with Target Response Accessibility Profiling (TRAP), a technique that captures conformational changes in situ by applying reductive dimethylation to label accessible lysine residues in living cells before lysis.
View Article and Find Full Text PDFPaper-immobilized liquid-phase microextraction for direct paper spray mass spectrometry and immuno-detection of atropine in baby food, buckwheat cereals, and edible oils at regulatory levels.
Anal Chim Acta
May 2025
Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, Wageningen, 6708 WE, the Netherlands; Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, Wageningen, 6708 WB, the Netherlands. Electronic address:
Background: Atropine is a strictly regulated natural toxin. Monitoring for atropine is thus important, but often expensive and time-consuming. Moreover, the range of relevant matrices, and corresponding differences in required detection limits for atropine vary.
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