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Discovery of Novel Thiazolohydrazone Derivatives as an Alternative Option in the Treatment of Zoonotic Toxocara canis: In Vitro and In Silico Evaluation.
Vet Med Sci
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Thiazoles serve as pharmacophores in many molecules that exhibit significant biological activity. This study used in vitro assays and in silico methodologies to identify novel medication candidates for preclinical evaluation of visceral toxocariasis treatment. The objective was to assess the impact of 11 thiazolohydrazone derivative compounds on the larval eggs of Toxocara canis.
View Article and Find Full Text PDFStudy of the Drug Resistance Function of Ivermectin-Resistance-Related miRNAs in Haemonchus contortus.
Acta Parasitol
January 2025
Ministry of Agriculture Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, College of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia Hohhot, Hohhot, China.
Haemonchus contortus has caused significant economic losses in many regions. The emergence of drug resistance has created new difficulties for the prevention and control of parasitic diseases in cattle and sheep. The mechanism of drug resistance to ivermectin in H.
View Article and Find Full Text PDFCymbopogon citratus showing nematicidal activity against Heligmosomoides polygyrus bakeri.
Rev Bras Parasitol Vet
January 2025
Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro - UENF, Campos dos Goytacazes, RJ, Brasil.
This paper describes a novel in vivo study of Cymbopogon citratus (lemon grass) to assess its anthelmintic activity. To this end, C57BL/6 mice were separated into three groups: G1: uninfected; G2: negative control infected with Heligmosomoides polygyrus bakeri and administered with 3% dimethyl sulfoxide (DMSO); and G3: infected with H. polygyrus bakeri and treated with C.
View Article and Find Full Text PDFBacillus velezensis A-27 as a potential biocontrol agent against Meloidogyne incognita and effects on rhizosphere communities of celery in field.
Sci Rep
January 2025
Laboratory of Nematology, Department of Plant Pathology, College of Plant Protection, Shanxi Agricultural University, Taigu, 030801, China.
Meloidogyne incognita, a highly destructive plant-parasitic nematode, poses a significant threat to crop production. The reliance on chemical nematicides for nematode control has been crucial; however, the banning of many effective nematicides due to their adverse effects has necessitated the exploration of alternative solutions. Rhizosphere biocontrol bacteria, particularly strains of Bacillus, have demonstrated promising results in managing plant-parasitic nematodes.
View Article and Find Full Text PDFSoil-transmitted helminthiasis among adolescents in Anaocha Local Government Area, Anambra State, Nigeria: Insights and recommendations for effective control.
PLoS One
January 2025
Neglected Tropical Diseases Division, Federal Ministry of Health, Abuja, Nigeria.
Over the past decade, Anambra State, Nigeria, has implemented mass administration of medicines (MAMs) to combat soil-transmitted helminthiasis (STH), a significant public health challenge in low-income regions. Nevertheless, these efforts have predominantly focused on pre-school and school-aged children, leaving a notable gap in understanding STH infection rates and the efficacy of these campaigns among secondary school adolescents, who have been excluded from this initiative. Our study aimed to address this critical knowledge gap by assessing soil-transmitted helminthiasis (STH) prevalence and contextual factors hindering effective control among adolescents in Anambra State, Nigeria.
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