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Anniston community health survey: Follow-up and dioxin analyses (ACHS-II)--methods.
Environ Sci Pollut Res Int
February 2016
Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA.
High serum concentrations of polychlorinated biphenyls (PCBs) have been reported previously among residents of Anniston, Alabama, where a PCB production facility was located in the past. As the second of two cross-sectional studies of these Anniston residents, the Anniston Community Health Survey: Follow-Up and Dioxin Analyses (ACHS-II) will yield repeated measurements to be used to evaluate changes over time in ortho-PCB concentrations and selected health indicators in study participants. Dioxins, non-ortho PCBs, other chemicals, heavy metals, and a variety of additional clinical tests not previously measured in the original ACHS cohort will be examined in ACHS-II.
View Article and Find Full Text PDFIntervention to reduce PCBs: learnings from a controlled study of Anniston residents.
Environ Sci Pollut Res Int
February 2016
Department of Pathology and Laboratory Medicine, University of Cincinnati, 2120 East Galbraith Road, Cincinnati, OH, 45237, USA.
Nonabsorbable dietary lipid reduces the absorption of dietary PCBs and increases the excretion of previously absorbed stored PCBs. Absorption of all PCB congeners will presumably be interrupted by nonabsorbable lipid; however excretion will be enhanced only for PCBs that have not been metabolized and also for their lipophilic metabolites. Our study with the nonabsorbable lipid, olestra, in a controlled trial in Anniston residents with elevated PCB levels demonstrated that it is possible to enhance removal of PCBs from the body in the clinically meaningful time frame of 1 year.
View Article and Find Full Text PDFVitamin D bioavailability: state of the art.
Crit Rev Food Sci Nutr
April 2016
a INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis , Marseille , France.
There has been renewed interest in vitamin D since numerous recent studies have suggested that besides its well-established roles in bone metabolism and immunity, vitamin D status is inversely associated with the incidence of several diseases, e.g., cancers, cardio-vascular diseases, and neurodegenerative diseases.
View Article and Find Full Text PDFSerum polychlorinated biphenyls (PCBs) in Anniston, AL, residents have been associated with hypertension and diabetes. There have been no systematic interventions to reduce PCB body burdens in Anniston or other populations. Our objective was to determine the efficacy of 15 g/day of dietary olestra to reduce PCBs in Anniston residents.
View Article and Find Full Text PDF[The pharmacological treatment of obesity: past, present and future].
Orv Hetil
March 2012
Pest Megyei Flór Ferenc Kórház, Kardiometabolikus Centrum V. Belgyógyászat-Lipidológiai Osztály, Regionális Zsíranyagcsere-központ és Hypertonia Decentrum, Budapest.
Article Synopsis
- Obesity is a major health issue, and effective management for weight loss includes lifestyle changes (like diet and exercise), behavioral therapy, pharmacological treatments, and sometimes surgery.
- While diet and exercise are ideal, they require discipline and can be tough to stick with; drug treatments can assist but often have modest results and lead to weight regain once stopped.
- Currently, orlistat is the only long-term anti-obesity drug approved, while new options like liraglutide are being researched for their potential in weight management.*
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