Lymphocytes and sera in mice with melanoma B16 and in intact mice render a cytotoxic effect on melanoma B16 cells in vitro. Lymphocytes in intact mice possess the maximum cytotoxicity for tumor cells, taken at the 20th day since the tumor inoculation, while the cytotoxic effect of mice melanoma B16 lymphocytes during this period proves to be markedly reduced. The kinetics of immune indices during the melanoma B16 growth in mice is characterized by rise and fall in the lymphocyte and sera cytotoxicity.
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