The rates of Cl- absorption and HCO3- secretion were not different in turtle urinary bladders bathed in Na+-free solutions. These results in turtle bladder are inconsistent with Na+-anion cotransport but can be accounted for by a Cl-/HCO3- exchange system.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0005-2736(80)90092-9DOI Listing

Publication Analysis

Top Keywords

chloride-bicarbonate exchange
4
exchange urinary
4
urinary bladder
4
bladder turtle
4
turtle independence
4
independence sodium
4
sodium ion
4
ion rates
4
rates cl-
4
cl- absorption
4

Similar Publications

Removal of arsenic from water by silver nanoparticles and Fe-Ce mixed oxide supported on polymeric anion exchanger.

J Environ Sci (China)

May 2025

Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan 430056, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Article Synopsis
  • A new nanocomposite, FeO(OH)-HCO-Ag-D201, was created by embedding goethite, ceric oxide, and silver nanoparticles in polystyrene to effectively remove arsenic from water.
  • Tests showed that this nanocomposite significantly increased the adsorption capacity for As(III) to 40.12 mg/g compared to 22.03 mg/g when AgNPs were not included.
  • The removal efficiency is influenced by pH levels and the presence of other substances, with the composite demonstrating strong potential for reusability in purifying arsenic-contaminated water.
View Article and Find Full Text PDF

Intestinal Epithelial Cell Brush Border Membrane Cl:HCO Exchanger Regulation by Mast Cells in Chronic Ileitis.

Int J Mol Sci

October 2024

Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.

Malabsorption of NaCl is the primary cause of diarrhea in inflammatory bowel disease (IBD). Coupled NaCl absorption occurs via the dual operation of Na:H and Cl:HCO exchange in the brush border membrane (BBM) of villus cells. Cl:HCO exchange is mediated by BBM transporters DRA (downregulated in adenoma) and PAT1 (putative anion transporter 1) in the mammalian small intestine.

View Article and Find Full Text PDF

Decreased expression of DRA () by a p38-driven IL-1α response contributes to diarrheal disease following in vivo challenge with spp.

Am J Physiol Gastrointest Liver Physiol

November 2024

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

In this study, we uncovered the novel mechanism of IL-1α-mediated downregulated in adenoma (DRA) () downregulation in the context of spp.induced malabsorptive diarrhea. Experimentally infected pigs with spp.

View Article and Find Full Text PDF

DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function.

JCI Insight

June 2024

Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition; and.

Duodenal bicarbonate secretion is critical to epithelial protection, as well as nutrient digestion and absorption, and is impaired in cystic fibrosis (CF). We examined if linaclotide, typically used to treat constipation, may also stimulate duodenal bicarbonate secretion. Bicarbonate secretion was measured in vivo and in vitro using mouse and human duodenum (biopsies and enteroids).

View Article and Find Full Text PDF

K-Driven Cl/HCO Exchange Mediated by Slc4a8 and Slc4a10.

Int J Mol Sci

April 2024

Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5090000, Chile.

Slc4a genes encode various types of transporters, including Na-HCO cotransporters, Cl/HCO exchangers, or Na-driven Cl/HCO exchangers. Previous research has revealed that Slc4a9 (Ae4) functions as a Cl/HCO exchanger, which can be driven by either Na or K, prompting investigation into whether other Slc4a members facilitate cation-dependent anion transport. In the present study, we show that either Na or K drive Cl/HCO exchanger activity in cells overexpressing Slc4a8 or Slc4a10.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!