The rates of Cl- absorption and HCO3- secretion were not different in turtle urinary bladders bathed in Na+-free solutions. These results in turtle bladder are inconsistent with Na+-anion cotransport but can be accounted for by a Cl-/HCO3- exchange system.
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http://dx.doi.org/10.1016/0005-2736(80)90092-9 | DOI Listing |
J Environ Sci (China)
May 2025
Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan 430056, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Int J Mol Sci
October 2024
Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Malabsorption of NaCl is the primary cause of diarrhea in inflammatory bowel disease (IBD). Coupled NaCl absorption occurs via the dual operation of Na:H and Cl:HCO exchange in the brush border membrane (BBM) of villus cells. Cl:HCO exchange is mediated by BBM transporters DRA (downregulated in adenoma) and PAT1 (putative anion transporter 1) in the mammalian small intestine.
View Article and Find Full Text PDFAm J Physiol Gastrointest Liver Physiol
November 2024
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
In this study, we uncovered the novel mechanism of IL-1α-mediated downregulated in adenoma (DRA) () downregulation in the context of spp.induced malabsorptive diarrhea. Experimentally infected pigs with spp.
View Article and Find Full Text PDFJCI Insight
June 2024
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition; and.
Duodenal bicarbonate secretion is critical to epithelial protection, as well as nutrient digestion and absorption, and is impaired in cystic fibrosis (CF). We examined if linaclotide, typically used to treat constipation, may also stimulate duodenal bicarbonate secretion. Bicarbonate secretion was measured in vivo and in vitro using mouse and human duodenum (biopsies and enteroids).
View Article and Find Full Text PDFInt J Mol Sci
April 2024
Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5090000, Chile.
Slc4a genes encode various types of transporters, including Na-HCO cotransporters, Cl/HCO exchangers, or Na-driven Cl/HCO exchangers. Previous research has revealed that Slc4a9 (Ae4) functions as a Cl/HCO exchanger, which can be driven by either Na or K, prompting investigation into whether other Slc4a members facilitate cation-dependent anion transport. In the present study, we show that either Na or K drive Cl/HCO exchanger activity in cells overexpressing Slc4a8 or Slc4a10.
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