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Robotic Pauli repair of parastomal hernia.
Surg Endosc
October 2024
Department of Gastroenterological Surgery, Sykehuset Innlandet Hospital Trust, Furnesvegen 26, N-2380, Brumunddal, Norway.
Background: Robotic retro-muscular mesh repair of parastomal hernia (PH) is possible with transversus abdominis release. The aim of this study is to report mid-term results with this method.
Methods: Patients who underwent surgery for PH were enrolled in a prospective study.
The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex.
Mol Cell
June 2024
Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. Electronic address:
Article Synopsis
- - The MYCN oncoprotein works with another protein called MAX to attach to active gene promoters, and it also connects with the nuclear exosome, indicating its role in RNA processing.
- - Research shows that MYCN forms large complexes with the exosome and various RNA-binding proteins, binding to RNA through a specific region known as MYCBoxI, which helps process many intronic RNA transcripts in cells.
- - Disrupting the exosome alters MYCN's position from gene promoters to intronic RNAs, leading to a shift in its role from activating genes to being replaced by a repressor (MNT/MXD6), which can limit its ability to influence cell growth while being crucial for neuroblastoma cell
Multimodal non-invasive probing of stress-induced carotenogenesis in the cells of microalga Bracteacoccus aggregatus.
Protoplasma
September 2024
Laboratory of Physics and Chemistry of Biological Membranes, Department of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow, 119234, Russia.
Microalgae are the richest source of natural carotenoids-accessory photosynthetic pigments used as natural antioxidants, safe colorants, and nutraceuticals. Microalga Bracteacoccus aggregatus IPPAS C-2045 responds to stresses, including high light, with carotenogenesis-gross accumulation of secondary carotenoids (the carotenoids structurally and energetically uncoupled from photosynthesis). Precise mechanisms of cytoplasmic transport and subcellular distribution of the secondary carotenoids under stress are still unknown.
View Article and Find Full Text PDFCentrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4 T cells.
Nat Commun
March 2024
Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observe that approximately 1-5% of CD4 T cells from the blood of people living with HIV-1 exhibit over-duplicated centrioles, suggesting that centrosome amplification underlies the development of HIV-1-associated cancers by driving aneuploidy.
View Article and Find Full Text PDFExcitation Energy Transfer between Higher Excited States of Photosynthetic Pigments: 2. Chlorophyll is a B Band Excitation Trap.
ACS Omega
October 2023
Department of Chemical Physics and Optics, Charles University, Ke Karlovu 3, 121 16 Prague 2, Czech Republic.
Chlorophylls (Chls) are known for fast, subpicosecond internal conversion (IC) from ultraviolet/blue absorbing ("B" or "Soret" states) to the energetically lower, red light-absorbing Q states. Consequently, excitation energy transfer (EET) in photosynthetic pigment-protein complexes involving the B states has so far not been considered. We present, for the first time, a theoretical framework for the existence of B-B EET in tightly coupled Chl aggregates such as photosynthetic pigment-protein complexes.
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