Clinical-laboratory observations were carried out on 40 patients with multiple plasmocytoma. Morbidity maximum was established to be during the fifth and sixth decade of life and that males are more frequently affected and bone manifestations are dominating initial symptoms. The anemic syndrome, the renal syndrome, erythrocyte sedimentation reaction and the data of the differential leukocyte count are discussed in details. Special attention is paid to the pathognomonic examinations in making the diagnosis: myelogram, electrophoresis and immunoelectrophoresis and bone roentgenography. The absence of changes in one of those examinations is concluded not to exclude the diagnosis multiple plasmocytoma as it is found in 10--20 per cent of the cases.

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