The concept that an absence of apoprotein B in plasma may result in increased cholesterol biosynthesis was investigated by sterol balance techniques in 2 male patients with abetalipoproteinemia, one an adult, the other a child. Total body synthesis of cholesterol in both the adult patient (19.3 +/- 3.8 mg/kg/day vs. 10.8 +/- 0.9 mg/kg/day in controls) and the child with abetalipoproteinemia (34.9 mg/kg/day vs. 14.5 +/- 3.8 mg/kg/day in control children) was significantly higher than in controls whereas bile acid synthesis was similar in both groups. Absorption of orally administered [1,2-3H]cholesterol was lower in the abetalipoproteinemic subjects than the controls and subsequent labeling of plasma cholesterol in the former patients was minimal (less than 3% of controls). The mechanisms for the increased sterol synthesis in abetalipoproteinemia may relate to the absence of chylomicrons and low density lipoproteins in plasma, but the magnitude of the increase can be largely explained on the basis of enhanced sterol losses that occur secondary to malabsorption of biliary cholesterol.

Download full-text PDF

Source

Publication Analysis

Top Keywords

+/- mg/kg/day
12
sterol balance
8
cholesterol
5
lipid metabolism
4
abetalipoproteinemia
4
metabolism abetalipoproteinemia
4
abetalipoproteinemia study
4
study cholesterol
4
cholesterol absorption
4
sterol
4

Similar Publications

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand.

Background: Our previous studies reported that D-galactose (D-gal) administration for four to eight weeks caused metabolic disturbance, brain mitochondrial dysfunction, and brain aging, leading to cognitive dysfunction in similar with natural aging condition. Spermidine is a polyamine that can be found naturally. Spermidine has been showed the beneficial effects on various models, such as attenuating metabolic/gut impairments in obesity, and ameliorating memory loss in aged model.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Xuanwu Hospital of Capital Medical University, Beijing, Beijing, China.

Background: Alzheimer's disease (AD), also known as senile dementia, is the most common degenerative disease of the central nervous system. Neuroinflammation is currently believed to be a crucial factor in the progression of AD, while its exact mechanism remains unclear.

Method: APP/PS1 AD mice were treated with a natural active ingredient tetrahydroxy stilbene glucoside (TSG) at 40 mg/kg/day and 80 mg/kg/day respectively for 5 consecutive months, and then the Morris water maze test (MWM) and the novel object recognition test were performed to assess the effect of TSG on the cognitive and memory ability of AD mice.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Doxorubicin (Dox), a chemotherapeutic agent, is known to cause chemobrain leading to cognitive decline and brain mitochondrial dysfunction. Ivabradine (Iva), hyperpolarization-activated cyclic nucleotide-gated channel blocker used for angina and arrhythmia, has been shown to be an anticonvulsant, antioxidant, and neuroprotective agent. However, the effects of Iva on cognitive function, and brain mitochondrial function in Dox-induced chemobrain are still not determined.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: An increase in the development of learning deficit occurred during estrogen-deprived periods via the increment of systemic and brain oxidative stress, brain apoptosis, and synaptic dysplasticity. Although estrogen supplementation has been shown to improve the brain function in estrogen-deprived conditions, it can lead to several adverse effects. Therefore, the novel therapeutic approach with minimal side effects to protect brain function in estrogen-deprived conditions should be further investigated.

View Article and Find Full Text PDF

Background: Loss of muscle mass and strength in patients who have experienced severe burns is dramatic and associated with subsequent functional impairment. Past work has shown that exercise and oxandrolone, an anabolic steroid, individually improve muscle function and muscle mass in severely burned patients. This study aims to evaluate the effect of oxandrolone treatment combined with resistance exercise on muscle atrophy and investigate the protein synthesis and mitochondrial biogenesis pathways in a hindlimb suspension model.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!