Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Multi-terminal flexible DC grid circuit breaker withstands multi-lightning strike analysis.
Sci Rep
January 2025
The State Key Laboratory of Collaborative Innovation Center for Smart Grid Fault Detection, Protection and Control Jointly, Kunming University of Science and Technology, Kunming, 650500, China.
Lightning represents the primary threat to power grids, with approximately 80% of natural occurrences being multi-lightning strikes, which have been extensively studied and confirmed to pose even more severe hazards. Hybrid DC circuit breakers (DCCBs) exhibit promising application prospects due to their superior interruption performance. During multi-lightning strikes, lightning intrusive waves pose a greater threat to the insulation of equipment such as hybrid DC fuses, fast mechanical switches, and insulated gate bipolar transistors.
View Article and Find Full Text PDFGenomics yields biological and phenotypic insights into bipolar disorder.
Nature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFCausal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study.
Transl Psychiatry
January 2025
Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Despite observational studies linking brain iron levels to psychiatric disorders, the exact causal relationship remains poorly understood. This study aims to examine the relationship between iron levels in specific subcortical brain regions and the risk of psychiatric disorders. Utilizing two-sample Mendelian randomization (MR) analysis, this study investigates the causal associations between iron level changes in 16 subcortical nuclei and eight major psychiatric disorders, including schizophrenia (SCZ), major depressive disorder (MDD), autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, and insomnia.
View Article and Find Full Text PDFMapping the cellular etiology of schizophrenia and complex brain phenotypes.
Nat Neurosci
January 2025
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Psychiatric disorders are multifactorial and effective treatments are lacking. Probable contributing factors to the challenges in therapeutic development include the complexity of the human brain and the high polygenicity of psychiatric disorders. Combining well-powered genome-wide and brain-wide genetics and transcriptomics analyses can deepen our understanding of the etiology of psychiatric disorders.
View Article and Find Full Text PDFA randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study).
J Psychopharmacol
January 2025
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Background: Options for 'treatment-resistant bipolar depression' (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option.
Aims: To evaluate the clinical effectiveness and safety of pramipexole in the management of TRBD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!