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Serial changes in metabolic dysfunction-associated steatotic liver disease after sleeve gastrectomy and their associations with abdominal adiposity: a prospective cohort study.
Surg Obes Relat Dis
November 2024
Bariatric and Metabolism International Surgery Center, E-Da Hospital, Kaohsiung, Taiwan; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. Electronic address:
Background: Little is known about the associations between changes in hepatic steatosis and changes in abdominal adiposity after metabolic bariatric surgery.
Objectives: To evaluate the serial changes in hepatic steatosis and abdominal adiposity following sleeve gastrectomy (SG).
Setting: University hospital, Taiwan.
The Status of Liver Margin in Perihilar Cholangiocarcinoma: A Multicenter Study.
Ann Surg
October 2024
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Key Laboratory of Digital Intelligence Hepatology, Ministry of Education, School of Clinical Medicine, Tsinghua University, Beijing, China.
Article Synopsis
- This study focused on the prevalence and distribution of carcinoma along the liver margin (LM) in patients with resected perihilar cholangiocarcinoma (pCCA) and aimed to improve examination methods for LM.!
- The research analyzed 227 pCCA cases, revealing a significantly higher rate of R1 resection (indicating the presence of cancer at the margin) in the group assessed with whole-mount digital large sections compared to those assessed with smaller sections.!
- Findings indicate that positive LM is a critical factor for poor surgical outcomes and suggest that precise examination within a 20 mm radius of the proximal ductal margin is necessary, particularly for patients with a margin of less than 5 mm, to enhance diagnostic
Several pseudolesions mimicking malignancy have been reported in cirrhotic and non-cirrhotic livers. Pericholecystic regeneration is among those pseudolesions and can occasionally mimic malignancy. Herein we present a case series comprised of 10 cirrhotic patients (majority due to alcoholic liver disease [ALD] or metabolic dysfunction associated steatotic liver disease [MASLD]) with pericholecystic observations initially categorized as highly suspicious for HCC (LR-4 and LR-5) due to their suspicious enhancement pattern which were later proven to be benign based on biopsy, transplantation or imaging criteria (stability of size and morphology on serial CT or MRI for > 2 years).
View Article and Find Full Text PDFAdvancing microvascular invasion diagnosis: a multi-center investigation of novel MRI-based models for precise detection and classification in early-stage small hepatocellular carcinoma (≤ 3 cm).
Abdom Radiol (NY)
September 2024
Department of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Purpose: This study aimed to develop two preoperative magnetic resonance imaging (MRI) based models for detecting and classifying microvascular invasion (MVI) in early-stage small hepatocellular carcinoma (sHCC) patients.
Methods: MVI is graded as M0 (no invasion), M1 (invasion of five or fewer vessels located within 1 cm of the tumor's peritumoral region), and M2 (invasion of more than five vessels or those located more than 1 cm from the tumor's surface). This study enrolled 395 early-stage sHCC (≤ 3 cm) patients from three centers who underwent preoperative gadopentetate-enhanced MRI.
Target Attainment and Population Pharmacokinetics of Nirmatrelvir/Ritonavir in Critically Ill Adult Patients.
Infect Drug Resist
September 2024
Department of Clinical Pharmaceutical, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Background: The population pharmacokinetics of nirmatrelvir/ritonavir (NIR/RIT) has not yet been described for critically ill adult patient.
Purpose: This was a prospective observational population pharmacokinetic study of nirmatrelvir/ritonavir (NIR/RIT) in critically ill adult patients and identify optimal dosing regimens.
Patients And Methods: The prescription of NIR/RIT is determined by the attending physician and ranges from 150mg/100mg to 300mg/100mg twice a day.
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