Through daily electrical stimulation of one of the hippocampi in the rabbit, EEG spikes were "kindled" in both hippocampi. Such hippocampi (termed kindled hippocampi) were then studied with the microelectrode in acute experiments. The electrical activities of the kindled hippocampus were characterized by spontaneous occurrence of hyperpolarizing potentials of various magnitudes (3-27 mV) and various durations (50-600 msec) in the pyramidal cell. These hyperpolarizations were never preceded by a prolonged spike burst. Furthermore, they could occur without any preceding depolarizations. They consisted of two components, i.e., Cl-dependent (somatic inhibitory postsynaptic potential) and C1-non-dependent (dendritic hyperpolarization) components. They were the main abnormal events occurring within the pyramidal cell of the kindled hippocampus. It was therefore considered that they were the intracellular correlates of the EEG spikes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2170/jjphysiol.31.879 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Response preparation is accomplished by gradual accumulation in neural activity until a threshold is reached. In humans, such a preparatory signal, referred to as the lateralized readiness potential, can be observed in the EEG over sensorimotor cortical areas before execution of a voluntary movement. Although well-described for manual movements, less is known about preparatory EEG potentials for saccadic eye movements in humans and nonhuman primates.
View Article and Find Full Text PDFLong-term outcome and predictors of vagus nerve stimulation for drug-resistant epilepsy: Real-world evidence from the Korean national hospital consortium.
Epilepsy Res
January 2025
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Objective: This study aimed to assess the long-term outcome and prognostic factors of vagus nerve stimulation (VNS) for drug-resistant epilepsy (DRE) using real-world data.
Method: We included 189 DRE patients who underwent VNS implantation between 2005 and 2018 at nine national hospitals in Korea. Seizure-frequency data obtained quarterly one year before and after surgery and annually up to four years after surgery were collected from medical records.
Neuronal mechanisms of nociceptive-evoked gamma-band oscillations in rodents.
Neuron
January 2025
State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:
Gamma-band oscillations (GBOs) in the primary somatosensory cortex (S1) play key roles in nociceptive processing. Yet, one crucial question remains unaddressed: what neuronal mechanisms underlie nociceptive-evoked GBOs? Here, we addressed this question using a range of somatosensory stimuli (nociceptive and non-nociceptive), neural recording techniques (electroencephalography in humans and silicon probes and calcium imaging in rodents), and optogenetics (alone or simultaneously with electrophysiology in mice). We found that (1) GBOs encoded pain intensity independent of stimulus intensity in humans, (2) GBOs in S1 encoded pain intensity and were triggered by spiking of S1 interneurons, (3) parvalbumin (PV)-positive interneurons preferentially tracked pain intensity, and critically, (4) PV S1 interneurons causally modulated GBOs and pain-related behaviors for both thermal and mechanical pain.
View Article and Find Full Text PDFAssociation of Sleep Spindle Rate With Memory Consolidation in Children With Rolandic Epilepsy.
Neurology
January 2025
Department of Neurology, Massachusetts General Hospital, Boston.
Background And Objectives: Rolandic epilepsy (RE), the most common childhood focal epilepsy syndrome, is characterized by a transient period of sleep-activated epileptiform activity in the centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation in animal models and healthy controls. Sleep spindles are decreased in RE and related sleep-activated epileptic encephalopathies.
View Article and Find Full Text PDFEpilepsy Prediction and Detection Using Attention-CssCDBN with Dual-Task Learning.
Sensors (Basel)
December 2024
Laboratory of Ethnic Language Intelligent Analysis and Security Governance of MOE, Minzu University of China, Beijing 100081, China.
Epilepsy is a group of neurological disorders characterized by epileptic seizures, and it affects tens of millions of people worldwide. Currently, the most effective diagnostic method employs the monitoring of brain activity through electroencephalogram (EEG). However, it is critical to predict epileptic seizures in patients prior to their onset, allowing for the administration of preventive medications before the seizure occurs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!