A comparative study on the Fernandez and on the Mitsuda reaction was made in 104 normal people employing whole and sonicated lepromin. Both types of lepromin can induce a good early reaction, and there was no significant difference in the results of the Fernandez reaction. The sonicated lepromin, though it contains all of the components of the original preparation, gives weaker late skin reactions. The results of the Mitsuda reaction were statistically significant.
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