28 patients, aged 35-62 years, with uncomplicated hypertension, entered a double-blind, crossover study, in which the effects of single daily doses of sotalol and metoprolol were compared. Both drugs exerted a clinically useful anti-hypertensive effect as monotherapy, or in combination with a thiazide diuretic. No significant difference in hypotensive effects was noted between the two beta-blocking agents, when the dose was titrated to an optimal clinical effect. Treatment with sotalol and metoprolol was associated with a clinically insignificant increase in serum uric acid concentration. The side-effects observed were few, and in only two cases was therapy discontinued. We regard both sotalol and metoprolol as useful anti-hypertensive drugs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00637506 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Real-world research on beta-blocker usage trends in China and safety exploration based on the FDA Adverse Event Reporting System (FAERS).
BMC Pharmacol Toxicol
November 2024
Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, 119 Nansihuan West Road, Fengtai District, Beijing, P. R. China.
Background: Beta-blockers are widely used, with continuously updated clinical recommendations. However, their application faces challenges in personalized treatment and safety. The study aimed to investigate the frequency and patterns of prescribing beta-blockers in China and to explore potential adverse event risk signals associated with beta-blockers, providing reference for rational medication use in clinical settings.
View Article and Find Full Text PDFIs the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions.
Environ Sci Pollut Res Int
March 2024
AdMaS Research Centre, Faculty of Civil Engineering, Brno University of Technology, Purkyňova 651/139, 612 00, Brno, Czech Republic.
Article Synopsis
- Wastewater-based epidemiology (WBE) is assessed for its reliability in estimating pharmaceutical consumption by comparing it to actual prescription data in urban areas.
- Most pharmaceuticals, like ciprofloxacin and metoprolol, showed a minimal difference (below 0.2 order of magnitude) between WBE estimates and control values, indicating good reliability, especially for sedatives.
- Seasonal patterns affected the load of specific drugs in the sewer system, but these changes did not significantly impact the reliability of WBE, suggesting it is a valid tool for estimating drug consumption despite some areas needing further research.
The role of plasma concentrations and drug characteristics of beta-blockers in fall risk of older persons.
Pharmacol Res Perspect
December 2023
Amsterdam UMC Location University of Amsterdam, Internal Medicine, Section of Geriatric Medicine, Amsterdam, The Netherlands.
Beta-blocker usage is inconsistently associated with increased fall risk in the literature. However, due to age-related changes and interindividual heterogeneity in pharmacokinetics and dynamics, it is difficult to predict which older adults are more at risk for falls. Therefore, we wanted to explore whether elevated plasma concentrations of selective and nonselective beta-blockers are associated with an increased risk of falls in older beta-blocker users.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!