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Introduction: Medial femoral cutaneous (MFC) sensory nerve action potentials (SNAPs) can be easily recorded using distal stimulation. This study aimed to identify a new parameter using MFC SNAPs for the early electrophysiological diagnosis of length-dependent axonal polyneuropathy (LDAP) associated with uremic neuropathy.

Methods: Patients with chronic renal failure who were referred to the electrodiagnostic laboratory due to symptoms suggesting polyneuropathy were included.

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Article Synopsis
  • The study looked at how often people in Romania got diabetic neuropathy (DN) and nondiabetic neuropathy (non-DN) from 2010 to 2019.
  • They found that more women had DN while more men had non-DN, and both types of neuropathy increased over the years, especially in people with type 2 diabetes.
  • The rise in non-DN cases was mostly due to other kinds of nerve problems like inflammatory polyneuropathies and uremic neuropathy, showing that both types of neuropathy are becoming more common.
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Article Synopsis
  • Uremic neuropathy (UN) is a painful nerve problem that affects many people with severe kidney disease who get dialysis for a long time.
  • This study looked at the size of different nerves in 10 patients with UN compared to 10 healthy people, using ultrasound and nerve tests.
  • The results showed that patients with UN had some nerve damage, but their nerves didn't get bigger like in other studies; instead, one type of nerve was actually smaller, suggesting a loss of nerve fibers.
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Background: Enteric infections and their chronic sequelae are a major cause of disability and death. Despite the increasing use of administrative health data in measuring the burden of chronic diseases in the population, there is a lack of validated International Classification of Disease (ICD) code-based case definitions, particularly in the Canadian context. Our objective was to validate ICD code definitions for sequelae of enteric infections in Canada: acute kidney injury (AKI); hemolytic uremic syndrome (HUS); thrombotic thrombocytopenic purpura (TTP); Guillain-Barré syndrome/Miller-Fisher syndrome (GBS/MFS); chronic inflammatory demyelinating polyneuropathy (CIDP); ankylosing spondylitis (AS); reactive arthritis; anterior uveitis; Crohn's disease, ulcerative colitis, celiac disease, erythema nodosum (EN); neonatal listeriosis (NL); and Graves' disease (GD).

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The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy.

Front Immunol

October 2022

Department of Urology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Article Synopsis
  • Uremic neuropathy in children is a serious problem affecting their nerves and overall health due to kidney issues.
  • It's often identified only after treatment like dialysis improves the child's symptoms because there's no specific test for it.
  • Researchers are exploring new ways to treat it, focusing on the body's immune response and reducing inflammation, rather than just kidney treatments.
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