Authors present a case of recurrent duodenal ulcer on the basis of Zollinger-Ellison syndrome. After two operations: vagotomy and gastric resection, it appear a gastrojejunocolic fistula produced by marginal ulceration following gastroenterostomy. Zollinger-Ellison syndrome is proved with echotomography of pancreas, examinations of gastrin, whose levels was high, as well as with examination of gastric secretion and biopsy of gastric mucosa. A total gastrectomy is performed as the safest surgical procedure, because all other operative treatments as vagotomy and resection's methods are of no help. Patient has recovered quickly after the operation with substitutional therapy. There was no more oedema, diarrhea, and he has recovered his working quality.
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