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Intestinal obstruction is a rare but life-threatening incidence in pregnancy. Diagnosis can be challenging for clinicians as the symptoms might be approached as other common obstetric complications. Performing radiological and abdominal surgery are also areas of great concern in this field; since radiologic studies inevitably expose the fetus to radiation and the treatment options mostly involve surgery that is worrisome during gestation.
View Article and Find Full Text PDFGenistein-3'-sodium sulfonate suppresses NLRP3-mediated cell pyroptosis after cerebral ischemia.
Metab Brain Dis
January 2025
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases of Ministry of Education, Gannan Medical University, Ganzhou, 341000, China.
Cerebral ischemia-induced pyroptosis contributes to the dissemination of neuroinflammation, and Nod-like receptor protein-3 (NLRP3) inflammasome plays a key role in this process. Previous studies have indicated that Genistein-3'-sodiumsulfonate (GSS) can inhibit neuroinflammation caused by cerebral ischemia, exert cerebroprotective effects, but its specific mechanism has not been comprehensively understood. The aim of this study was to explore the effect of GSS on ischemic stroke-induced cell pyroptosis.
View Article and Find Full Text PDFThe Black Esophagus: A Rare Case Presentation.
Cureus
December 2024
Gastroenterology and Hepatology, Saint Peter's University Hospital, New Brunswick, USA.
Acute esophageal necrosis (AEN), also known as black esophagus or Gurvits syndrome, is an uncommon endoscopic finding characterized by diffuse, circumferential, black discoloration of the esophagus that terminates at the gastroesophageal junction. The incidence of AEN has been reported to be 0-0.2% in autopsy series and up to 0.
View Article and Find Full Text PDFAbout bacteriophage tail terminator and tail completion proteins: structure of the proximal extremity of siphophage T5 tail.
J Virol
December 2024
Université Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
Bacteriophages are viruses infecting bacteria. The vast majority of them bear a tail, allowing host recognition, cell wall perforation, and DNA injection into the host cytoplasm. Using electron cryo-microscopy (cryo-EM) and single particle analysis, we determined the organization of the tail proximal extremity of siphophage T5 that possesses a long flexible tail and solved the structure of its tail terminator protein p142 (TrP).
View Article and Find Full Text PDFThe Performance of a New Nanosecond Pulsed Field Ablation Surgical Clamp in Ablation of Cardiac Tissue: A Chronic Porcine Model.
J Thorac Cardiovasc Surg
December 2024
Department of Surgery, Division of Cardiac Surgery, Johns Hopkins University, Baltimore, MD.
Article Synopsis
- The study evaluated the safety and effectiveness of a new device, the nsPFA Parallel Clamp, for ablating cardiac tissue in pigs, testing its ability to create lesions in all four heart chambers using short high-amplitude electrical pulses.
- Results showed that the nsPFA group had no serious device-related issues, while the radiofrequency group experienced complications, including one death and thrombotic events.
- Histopathological analysis revealed consistent scar formation in the nsPFA group, indicating successful ablation, while the radiofrequency group had a lower rate of complete scar maturation, suggesting that the nsPFA system is a promising alternative for cardiac tissue ablation.
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