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Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study.
BMC Nutr
January 2025
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Background: Recent studies suggest a link between dietary fat quality and obesity. Genetic risk scores (GRS) can predict obesity risk based on genetic factors. This study investigates how GRS and fatty acid quality affect visceral adiposity index (VAI) and body adiposity index (BAI) in overweight and obese women.
View Article and Find Full Text PDFNon-targeted metabolomics reveals fatty acid and associated pathways driving resistance to whitefly and tomato leafminer in wild tomato accessions.
Sci Rep
January 2025
World Vegetable Center, 60 Yi-Min Liao, Shanhua, Tainan, 74151, Taiwan.
Wild tomato species exhibit natural insect resistance, yet the specific secondary metabolites and underlying mechanisms governing the resistance remain unclear. Moreover, defense expression dynamically adapts to insect herbivory, causing significant metabolic changes and species-specific secondary metabolite accumulation. The present study aims to identify the resistance-related metabolites in wild tomato accessions that influence the defense mechanism against whitefly (Bemisia tabaci Asia II 7) and leafminer (Phthorimaea absoluta).
View Article and Find Full Text PDFIntegrating machine learning models for optimizing ecosystem health assessments through prediction of nitrate-N concentrations in the lower stretch of Ganga River, India.
Environ Sci Pollut Res Int
January 2025
ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata, 700120, West Bengal, India.
Nitrate, a highly reactive form of inorganic nitrogen, is commonly found in aquatic environments. Understanding the dynamics of nitrate-N concentration in rivers and its interactions with other water-quality parameters is crucial for effective freshwater ecosystem management. This study uses advanced machine learning models to analyse water quality parameters and predict nitrate-N concentrations in the lower stretch of the Ganga River from the observations of six annual periods (2017 to 2022).
View Article and Find Full Text PDFPhytotoxic impact of di-butyl phthalate (DBP) on physiological, biochemical, and oxidative stress parameters of rice (Oryza sativa).
Environ Sci Pollut Res Int
January 2025
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Phthalates are synthetic compounds, well-known plasticizers, with numerous applications and reported to have adverse effects on all living organisms residing in terrestrial and aquatic environments. In this study, the rice (Oryza sativa) seedlings were exposed to di-butyl phthalate (DBP) exogenously for 7 days, with varying concentrations of 0, 200, 400, 800, and 1600 mg/L, to explore the toxicological, physiological, and biochemical consequences by measuring various parameters such as pigment, lipid, and HO (hydrogen peroxide) contents. The biochemical analysis of seedlings showed that the pigments, lipids, and HO concentrations were altered abnormally.
View Article and Find Full Text PDFDiscovery of pyrazoline analogs as multi-targeting cholinesterase, β-secretase and Aβ aggregation inhibitors through lead optimization strategy.
Int J Biol Macromol
January 2025
Pharmaceutical Chemistry Research Laboratory I, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India. Electronic address:
The multi-target directed ligands (MTDLs) strategy has been evolved as the propitious approach for the development of therapeutics for Alzheimer's disease (AD). In an earlier report, we described the novel series of chalcone derivatives bearing N-aryl piperazine scaffold as MTDLs for the treatment of AD. Herein, we report the lead optimization of the series culminating in potent, multi-targeting compounds (32-57), evaluated through in-vitro and in-vivo biological studies.
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