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Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline.
Amino Acids
December 2024
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697-3900, USA.
Collapsin response mediator protein 2 (CRMP2) functions in the genesis and activity of neuronal connections in mammalian brain. We previously reported that a protein coincident with CRMP2 on 2D-gels undergoes marked accumulation of abnormal L-isoaspartyl sites in brain extracts of mice missing the repair enzyme, protein L-isoaspartyl methyltransferase (PIMT). To confirm and explore the significance of isoaspartyl damage in CRMP2, we expressed and purified recombinant mouse CRMP2 (rCRMP2).
View Article and Find Full Text PDFTakotsubo Cardiomyopathy in Epilepsy: A Systematic insight into the Existing Literature from 2000-2023.
Pak J Med Sci
December 2024
Professor Asif Bashir, Punjab Institute of Neurosciences, Lahore, Punjab, Pakistan.
Background & Objective: Takotsubo cardiomyopathy (TCM), manifests as left ventricular dysfunction triggered by physical or emotional stress. It leads to higher morbidity in epileptic patients and can progress to complications. To find out the correlation between Takotsubo cardiomyopathy and epilepsy and to investigate pathophysiology and associated types of epilepsy.
View Article and Find Full Text PDFCollapsin response mediator protein 2 (CRMP2) functions in the genesis and activity of neuronal connections in mammalian brain. We previously reported that a protein coincident with CRMP2 on 2D-gels undergoes marked accumulation of abnormal L-isoaspartyl sites in brain extracts of mice missing the repair enzyme, protein L-isoaspartyl methyltransferase (PIMT). To conflrm and explore the signiflcance of isoaspartyl damage in CRMP2, we expressed and purifled recombinant mouse CRMP2 (rCRMP2).
View Article and Find Full Text PDFMultiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicotine consumption as risk factors.
Epilepsia Open
November 2024
Department of Neurology, Neurocritical Care, and Neurorehabilitation, Center for Cognitive Neuroscience, European Reference Network EpiCARE, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria.
Article Synopsis
- - A 20-year-old man with drug-resistant epilepsy developed multiple intracerebral hemorrhages after receiving stereo-EEG electrodes and experiencing a lumbar spinal tap, with a history of heavy use of nicotine pouches.
- - Genetic testing revealed a mutation in the COL4A2 gene, which is linked to collagen production and has previously been associated with hemorrhage risks, raising concerns about its role in the patient's complication.
- - The study suggests that the combination of the COL4A2 mutation and high nicotine use could significantly increase the likelihood of bleeding during neurosurgical procedures, calling for more research into this connection.
Phenotypic characterization and quality of life of Labradoodles with idiopathic epilepsy and epilepsy of unknown cause.
Front Vet Sci
October 2024
Expertise Centre of Genetics, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Article Synopsis
- Idiopathic epilepsy (IE) is a chronic neurological disorder affecting Labradoodles, with a specific focus on characterization including age of onset, seizure frequency, and impact on quality of life for both dog and owner.
- An online survey involving Labradoodle owners revealed that 33 out of 40 dogs either had IE or were suspected of having it, with an average age of onset at 2.3 years and an average seizure frequency of 5.4 seizures per year; stress was the most common trigger for seizures.
- Despite some dogs experiencing severe forms of epilepsy, such as cluster seizures and status epilepticus, a majority managed well with minimal treatment, reflecting high quality of life scores for both the dogs
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