The early and late effect of three anticholinesterase agents (physostigmine, paraoxon and soman) on core temperature and brain acetylcholinesterase (AcChE) inhibition are compared. The study was performed in adult male rats using sublethal doses of all drugs. AcChE activity was determined by hypothalamus, striatum, hippocampus, medulla oblongata-pons and rest of the brain. The co-existence of intoxication symptoms, hypothermia and AcChE inhibitions was clearly shown by the early effects. However, no relationship was found between the degree of hypothermia and that of inhibition whatever brain area. In contrast, late AcChE inhibition was not accompanied by symptoms and lowering of core temperature. Several hypotheses have been suggested to explain this phenomenon: de novo synthesis of enzyme, decreased sensitivity of neurotransmitter or return to normal of brain acetylcholine level through a negative feed back at the presynaptic level. The present data suggest that this latter assumption is the most likely.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0773.1981.tb00896.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Agricultural Practices and Environmental Factors Drive Microbial Communities in the Mezcal-Producing Agave angustifolia Haw.
Microb Ecol
January 2025
Ciencias Agrogenómicas, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, León, Guanajuato, México.
Mezcal, a traditional Mexican alcoholic beverage, has been a vital source of livelihood for indigenous and rural communities for centuries. However, increasing international demand is exerting pressure on natural resources and encouraging intensive agricultural practices. This study investigates the impact of management practices (wild, traditional, and conventional) and environmental factors on the microbial communities associated with Agave angustifolia, a key species in mezcal production.
View Article and Find Full Text PDFPrecise morphology control of all-organic core-shell droplets for synthesis of microencapsulated phase change materials through AC electric fields.
J Colloid Interface Sci
January 2025
National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics, Research Institute of Aero-Engine, Beihang University, Beijing 100191, China. Electronic address:
Hypothesis: Complex emulsions usually consist of aqueous phases, like oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w), serving foundational roles in colloid science. Oil-in-oil-oil (o/o/o) emulsions offer new avenues for non-aqueous reagents but face challenges in balancing the forces between multiple organic phases.
Experiments: In this work, we generate o/o/o emulsions by integrating an AC electric field with a double cross-junction microchannel.
Strong precursor softening in cubic CaSiO perovskite.
Proc Natl Acad Sci U S A
February 2025
Department of Earth Sciences, University College London, London WC1E 6BT, United Kingdom.
CaSiO[Formula: see text] perovskite (CaPv) is the last major mineral in the Earth's lower mantle whose elasticity remains largely unresolved. Here, we investigate the elasticity of CaPv using ab initio machine-learning force fields (MLFF). At room temperature, the elasticity of tetragonal CaPv determined by MLFF molecular dynamics (MD) agrees well with experimental measurements after considering temperature induced variations in the hydrostatic structure, proving the effectiveness of the method.
View Article and Find Full Text PDFReactivity of Wet scCO toward Reservoir and Caprock Formations under Elevated Pressure and Temperature Conditions: Implications for CCS and CO-Based Geothermal Energy Extraction.
Energy Fuels
January 2025
Geothermal Energy and Geofluids Group, Institute of Geophysics, Department of Earth and Planetary Sciences, ETH Zurich, Zurich 8092, Switzerland.
Carbon capture and storage (CCS) and CO-based geothermal energy are promising technologies for reducing CO emissions and mitigating climate change. Safe implementation of these technologies requires an understanding of how CO interacts with fluids and rocks at depth, particularly under elevated pressure and temperature. While CO-bearing aqueous solutions in geological reservoirs have been extensively studied, the chemical behavior of water-bearing supercritical CO remains largely overlooked by academics and practitioners alike.
View Article and Find Full Text PDFTissue-specific responses to oxidative fuel source preference during heat stress in lactating dairy cows.
JDS Commun
January 2025
School of Animal Sciences, Virginia Tech, Blacksburg, VA 24061.
Prolonged exposure to high environmental temperatures results in an accumulated heat load that induces a heat stress (HS) response in dairy cattle. Heat stress compromises dairy farm profitability by reducing milk yield, altering milk composition, and hindering reproductive performance. The ability to alternate between carbohydrate and lipid sources for energy production is termed metabolic flexibility (Met Flex).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!