Harman, but not norharman, induced sister-chromatid exchanges in human peripheral lymphocytes in vitro. Transcription of isolated DNA in vitro was inhibited by both compounds, harman being more effective than norharman. A filter-binding assay with isolated DNA showed that harman binds more effectively to the DNA than norharman.
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| http://dx.doi.org/10.1016/0165-1218(81)90065-3 | DOI Listing |
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