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Cytomegalovirus Infection in an Immunocompetent Host Presenting as Hemophagocytic Lymphohistiocytosis.
Eur J Case Rep Intern Med
December 2024
Department of Internal Medicine, Hospital de Santa Maria, ULS de Santa Maria, Lisbon, Portugal.
Unlabelled: Cytomegalovirus (CMV) is a human herpes virus with a worldwide seroprevalence of 60-100%, mainly known to cause severe life-threatening disease in immunocompromised patients. In immunocompetent hosts (IMCh), CMV causes a self-limiting mononucleosis-like infection, and severe pictures are less recognized. We report a case of a previously healthy 62-year-old woman evaluated in the Internal Medicine outpatient clinic for 3 weeks of progressive fatigue, generalised inflammatory arthralgias, hypogastric discomfort and daily persistent fever.
View Article and Find Full Text PDFPrevalence and Predictive Factors of Sickle Cell Emergencies Readmission in the Clinical Hematology Department of Dakar, Senegal.
Anemia
November 2024
Hematology Department, Cheikh Anta Diop University, Dakar, Senegal.
Article Synopsis
- Sickle cell emergencies are a leading reason for hospitalizations in patients with sickle cell disease, causing significant financial strain and increased health risks.
- A study tracked 112 adults with sickle cell emergencies over four months, revealing a 38.41% readmission rate within 30 days, predominantly due to vaso-occlusive crises and acute chest syndrome.
- Key factors predicting readmission included having a job, low levels of fetal hemoglobin, and certain blood cell counts (neutrophilia, lymphocytosis, thrombocytosis).
Myeloproliferative Neoplasm-like Mutations of Calreticulin Induce Phenotypes Associated with Calreticulin Dysfunction in .
Int J Mol Sci
October 2024
Department of Biochemistry and Genetics, School of Sciences, University of Navarra, 31008 Pamplona, Spain.
In previous research, we created a model with homozygous mutations in calreticulin similar to those found in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), two myeloproliferative neoplasms (MPNs). This model, lacking JAK orthologs, enabled us to examine the transcriptomic effects caused by mutant calreticulin without the influence of JAK/STAT activation, the primary pathogenic mechanism associated with calreticulin mutations known to date. Most of the gene expression changes observed seemed to be due to a partial loss of protein function, with the alteration of the extracellular matrix being particularly notable.
View Article and Find Full Text PDFThe chicken or the egg? complicated by left ventricle thrombus and anterior myocardial infarction: a case report.
Eur Heart J Case Rep
September 2024
Icahn School of Medicine at Mount Sinai, The Zena and Michael A. Wiener Cardiovascular Institute, New York, NY 10029, USA.
Background: can be associated with extrapulmonary manifestations, including vasculitis, myocarditis, and thrombosis. In rare cases, it has also been implicated in intracardiac thrombus formation.
Case Summary: A previously healthy 25-year-old male presented with worsening abdominal pain, an episode of acute chest pain, new lightheadedness, and gait instability in the setting of .
Clinical impact of mutated JAK2 allele burden reduction in polycythemia vera and essential thrombocythemia.
Am J Hematol
August 2024
CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, DMSC, University of Florence, AOU Careggi, Florence, Italy.
The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains debated. We prospectively measured changes in JAK2 and CALR VAF in 77 patients with polycythemia vera and essential thrombocythemia, treated with ruxolitinib for a median of 8 years, and assessed correlation with complete clinical and hematological response (CCHR) and outcomes.
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