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Lupus nephritis and related renal disease: review from case series.
Clin Exp Nephrol
December 2024
Department of Pathology, Toranomon Hospital, Tokyo, Japan.
Renal lesions due to systemic lupus erythematosus (SLE) are defined as lupus nephritis (LN), a renal disease characterized by the deposition of immunoglobulin (Ig)G-based immune complexes in the kidney and the appearance of double-stranded DNA and Smith antibodies. In particular, deposition of IgG3, which has strong complement binding properties, under the endothelium or in the mesangium activates the classical complement pathway of C1q, C4, and C3, leading to renal damage. This step is followed by migration of inflammatory cells, including neutrophils and monocytes, which induce inflammation in the glomerular capillaries and cause mesangiolysis and endothelial cell damage, resulting in endocapillary proliferative nephritis.
View Article and Find Full Text PDFIgG1 versus IgG3: influence of antibody-specificity and allotypic variance on virus neutralization efficacy.
Front Immunol
November 2024
Institute of Plant Biotechnology and Cell Biology, Department of Applied Genetics and Cell Biology, BOKU University, Vienna, Austria.
Despite the unique advantages of IgG3 over other IgG subclasses, such as mediating enhanced effector functions and increased flexibility in antigen binding due to a long hinge region, the therapeutic potential of IgG3 remains largely unexplored. This may be attributed to difficulties in recombinant expression and the reduced plasma half-life of most IgG3 allotypes. Here, we report plant expression of two SARS-CoV-2 neutralizing monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding.
View Article and Find Full Text PDFDesensitization of Highly Immunized Kidney Transplant Recipients Awaiting Transplantation-Polish Single-Center Experience.
Transplant Proc
May 2024
Department of Nephrology, Transplantology and Internal Medicine; Medical University of Gdańsk, Gdańsk, Poland.
Introduction: The increasing number of highly immunized patients waiting for kidney transplantation is a significant problem in Europe as the proportion of such patients has doubled in the last decade. Transplantation in this group is enabled by desensitization methods, i.e.
View Article and Find Full Text PDFAntiphospholipid syndrome pathogenesis in 2023: an update of new mechanisms or just a reconsideration of the old ones?
Rheumatology (Oxford)
February 2024
Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Antibodies against phospholipid (aPL)-binding proteins, in particular, beta 2 glycoprotein I (β2GPI), are diagnostic/classification and pathogenic antibodies in antiphospholipid syndrome (APS). β2GPI-aPL recognize their target on endothelium and trigger a pro-thrombotic phenotype which is amplified by circulating monocytes, platelets and neutrophils. Complement activation is required as supported by the lack of aPL-mediated effects in animal models when the complement cascade is blocked.
View Article and Find Full Text PDF[Tandem mass tag-based quantitative proteomics analysis of plasma and plasma exosomes in Parkinson's disease].
Se Pu
December 2023
Department of Geriatrics, Second Hospital of Hebei Medical University, Shijiazhuang 050051, China.
The cardinal clinical features of Parkinson's disease (PD), a common neurodegenerative disease, include the irreversible impairment of movement coordination, such as tremors, gait rigidity, bradykinesia, and hypokinesia. Although various factors are associated with the pathological changes in PD, such as oxidative stress, mitochondrial dysfunction, and neuroinflammation, the availability of treatments to retard PD progression is limited. Therefore, novel biomarkers for PD diagnosis and therapeutic targets are urgently needed.
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