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Hemoperfusion with the HA330/HA380 Cartridge in Intensive Care Settings: A State-Of-The-Art Review.
Blood Purif
November 2024
Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.
Article Synopsis
- Hemoperfusion using the HA330/HA380 cartridge has become popular in ICUs over the last decade for treating critical illnesses by removing inflammatory substances from the blood.
- While numerous studies indicate its potential benefits in reducing inflammation and organ failure, there is still no comprehensive assessment of its safety and effectiveness in critical care.
- This paper aims to review the HA330/HA380 hemoperfusion technique, summarize recent clinical findings across various conditions, and highlight drug clearance capabilities to address safety issues.
Regenerated carboxymethyl cellulose beads for selective removal of low-density lipoprotein from whole blood.
Carbohydr Polym
January 2025
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR China. Electronic address:
Low-density lipoprotein (LDL) plays a crucial role in the development of cardiovascular disease. Lowering the level of LDL is an effective therapeutic strategy for treating cardiovascular disease. Here, we developed a facile and robust method to prepare carboxymethyl cellulose beads (CMCBs) for selectively adsorbing LDL.
View Article and Find Full Text PDFMesoporous activated carbon derived from Chinese herbal medicine residues for hemoperfusion removal of uremia toxins from progressive chronic kidney diseases patients.
Heliyon
October 2024
Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, PR China.
Article Synopsis
- Hemoperfusion is a key treatment for chronic kidney disease (CKD) and works by filtering toxins from the blood, making the efficiency of adsorbents used crucial for effective therapy.
- This study focuses on using carbonized and activated areca nut shells, a common waste material, to create porous adsorbents that are tested for their ability to remove toxins from blood.
- Results indicate that these new adsorbents are more effective than traditional ones, significantly reducing uremic toxins in both simulated and actual blood samples from CKD patients and animal models, showcasing their potential for enhancing treatment outcomes in progressive CKD.
Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup.
Nephrol Dial Transplant
November 2024
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany; and Outcomes Research Consortium, Cleveland, OH, USA.
Adsorption-based extracorporeal therapies have been subject to technical developments and clinical application for close to five decades. More recently, new technological developments in membrane and sorbent manipulation have made it possible to deliver more biocompatible extracorporeal adsorption therapies to patients with a variety of conditions. There are several key rationales based on physicochemical principles and clinical considerations that justify the application and investigation of such therapies as evidenced by multiple ex vivo, experimental and clinical observations.
View Article and Find Full Text PDFHemoadsorption Therapy for Calcium Channel Blocker Overdose: A Case Report.
J Emerg Med
April 2024
Department of Critical Care, School of Clinical Medicine/University of Witwatersrand/Chris Hani Baragwanath, Johannesburg, South Africa.
Background: Modern resin hemoadsorption/hemoperfusion for calcium channel blocker overdose is yet to be reported. The characteristics of calcium channel blockers make them unamenable to removal by hemodiafiltration or charcoal hemoperfusion; however, elimination, using styrene bead adsorption in an ex vivo model, has been demonstrated. Its clinical use is described.
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