An infant presented in the first week postpartum with markedly elevated serum osmolality of unknown origin. The cryptic osmols were identified as glycerol and alcohol and were traced to the contents of local phenobarbitone elixir administered to control neonatal convulsions. This report highlights the importance of recognizing the potential dangers inherent in the nominally inert components of medication and stresses the extreme care required when modifying well-established formulations.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Contribution of Plasma Urea to Total Osmolality During Iatrogenic Fluid Reduction in Critically Ill Patients.
Function (Oxf)
January 2023
Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, SE-751 05 Uppsala, Sweden.
Hyperosmolality is common in critically ill patients during body fluid volume reduction. It is unknown whether this is only a result of decreased total body water or an active osmole-producing mechanism similar to that found in aestivating animals, where muscle degradation increases urea levels to preserve water. We hypothesized that fluid volume reduction in critically ill patients contributes to a shift from ionic to organic osmolytes similar to mechanisms of aestivation.
View Article and Find Full Text PDFComparison of Complications, Trends, and Costs in Endoscopic vs Microscopic Pituitary Surgery: Analysis From a US Health Claims Database.
Neurosurgery
September 2017
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland.
Background: Microsurgical and endoscopic techniques are commonly utilized surgical approaches to pituitary pathologies. There are limited data comparing these 2 procedures.
Objective: To evaluate postoperative complications, associated costs, and national and regional trends of microscopic and endoscopic techniques in the United States employing a nationwide database.
A Case of Osmotic Demyelination Presenting with Severe Hypernatremia.
Electrolyte Blood Press
June 2015
Department of Internal Medicine, National Rehabilitation Center, Seoul, Korea.
Osmotic demyelination syndrome is a demyelinating disorder associated with rapid correction of hyponatremia. But, it rarely occurs in acute hypernatremia, and it leads to permanent neurologic symptoms and is associated with high mortality. A 44-year-old woman treated with alternative medicine was admitted with a history of drowsy mental status.
View Article and Find Full Text PDFPropylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study.
Chest
September 2005
The Pulmonary Center, R-304, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA.
Study Objectives: Benzodiazepines are commonly administered to medical ICU (MICU) patients. Propylene glycol (1,2-propanediol) is the solvent used to deliver lorazepam and diazepam IV. Although propylene glycol toxicity is increasingly recognized and reported, its incidence is unknown.
View Article and Find Full Text PDFAn infant presented in the first week postpartum with markedly elevated serum osmolality of unknown origin. The cryptic osmols were identified as glycerol and alcohol and were traced to the contents of local phenobarbitone elixir administered to control neonatal convulsions. This report highlights the importance of recognizing the potential dangers inherent in the nominally inert components of medication and stresses the extreme care required when modifying well-established formulations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!