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Outcomes of total cystectomy with medical treatment in canine urothelial carcinoma of the bladder trigone.
Can Vet J
March 2025
Veterinary Medical Center (Takahashi, Motegi, Fujita, Hashimoto) and Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences (Kato, Nakagawa, Nishimura) and Laboratory of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences (Maeda), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Objective: This study aimed to evaluate outcomes and complications in dogs with urothelial carcinoma (UC) of the bladder trigone treated with total cystectomy using uretero-prepuce/vagina/cutaneous anastomosis combined with medical treatment.
Animals: Twenty-one dogs.
Procedure: Total cystectomy was completed as follows: The whole bladder and urethra were removed, and the ureters were anastomosed to the skin in 1 case and to the vagina in 9 cases in females.
Enfortumab Vedotin With or Without Pembrolizumab in Metastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis.
JAMA Netw Open
March 2025
Department of Urology, National Cancer Center Hospital East, Chiba, Japan.
Importance: Metastatic urothelial carcinoma (mUC) presents a therapeutic challenge with poor outcome. Enfortumab vedotin has emerged as a promising treatment, necessitating a comprehensive evaluation of its effectiveness and safety.
Objective: To synthesize the available evidence on enfortumab vedotin, both as monotherapy and in combination with pembrolizumab, as an mUC treatment for the purpose of guiding clinical decision-making and future research.
A histopathological snapshot of bladder cancer: a Johannesburg experience of 1480 histopathology reports.
World J Urol
March 2025
Department of Anatomical Pathology, University of the Witwatersrand, /National Health Laboratory Services, Johannesburg, South Africa.
Purpose: To evaluate the histopathological characteristics of bladder cancer in patients presenting to Johannesburg hospitals over a 13-year period (2010-2023).
Methods: Following ethical clearance, a retrospective observational, descriptive review of histopathological reports over 13 years was conducted in Johannesburg. Inclusion criteria was bladder biopsies, TURBT specimens, and radical cystectomy (RC) specimens positive for bladder cancer.
Prognostic Factors Influencing Postoperative Survival in Patients With Neuroendocrine Carcinoma of the Bladder: A Population-Based Study.
Cancer Med
March 2025
Department of Urology, Urologic Surgery Center, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Background: This study aimed to identify prognostic factors influencing survival in patients with bladder neuroendocrine carcinoma (NC).
Methods: This study utilized the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015) to compare NC with urothelial carcinoma (UC). We evaluated the prognostic value of clinicopathological characteristics and survival outcomes for bladder NC patients.
Diagnostic workout of glandular malignant lesions of the bladder according to the 5th WHO classification.
Crit Rev Clin Lab Sci
March 2025
Department of Urology and Renal Transplantation, Policlinico Foggia, University of Foggia, Foggia, Italy.
Glandular lesions involving the bladder are less common than conventional urothelial carcinoma, and they are often diagnostically challenging diseases, carrying different clinical outcomes. As a group, they encompass both primary and secondary neoplasms, with sometimes overlapping morphological features. In this scenario, proper clinical information is important, in that secondary involvement of the bladder may occur by direct extension or lymphatic/hematogenous spread from carcinomas at other sites, comprising prostate, colon, cervix, breast, and lung.
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