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Retrospective evaluation of acid-base analysis in dogs and cats with diabetic ketosis (2017-2021): 96 cases.
J Vet Emerg Crit Care (San Antonio)
January 2025
Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Objective: To describe the acid-base balance of diabetic animals with ketosis and to identify underlying mechanisms of acid-base changes using semiquantitative analysis.
Design: Retrospective study.
Setting: University teaching hospital.
Integrated system for electrolyte recovery, product separation, and CO capture in CO reduction.
Nat Commun
January 2025
School of Environment and Energy, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, South China University of Technology, Guangzhou, 510006, China.
Challenges in CO capture, CO crossover, product separation, and electrolyte recovery hinder electrocatalytic CO reduction (COR). Here, we present an integrated electrochemical recovery and separation system (ERSS) with an ion separation module (ISM) between the anode and cathode of a water electrolysis system. During ERSS operation, protons from the anolyte flow through the anodic cation exchange membrane (CEM) into the ISM, acidifying the COR effluent electrolyte.
View Article and Find Full Text PDFNavigating the aftermath: Risk factors of recurrence following coronary bypass surgery in Indonesia.
Narra J
December 2024
Department of Health Services Research and Management, School of Health and Psychological Sciences, City University of London, London, United Kingdom.
Coronary heart disease (CHD) remains a leading cause of mortality in Indonesia, and coronary artery bypass graft (CABG) surgery is frequently employed to manage arterial blockages. Despite its efficacy, the recurrence of heart disease post-surgery is a significant concern, highlighting the need for a deeper understanding of its influencing factors. The aim of this study was to examine the factors associated with the incidence of heart disease recurrence after coronary bypass surgery.
View Article and Find Full Text PDFThe study aimed to verify the physiological and metabolic parameters associated with the time to task failure (TTF) during cycling exercise performed within the severe-intensity domain. Forty-five healthy and physically active males participated in two independent experiments. In experiment 1, after a graded exercise test, participants underwent constant work rate cycling efforts (CWR) at 115% of peak power output to assess neuromuscular function (Potentiated twitch) pre- and post-exercise.
View Article and Find Full Text PDFDiscovery of a Potent Triazole-Based Reversible Targeted Covalent Inhibitor of Cruzipain.
ACS Med Chem Lett
January 2025
Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Leuven 3000, Belgium.
Cruzipain (CZP) is an essential cysteine protease of , the etiological agent of Chagas disease, and a promising druggable target. To date, no CZP inhibitors have reached clinical use, with research efforts mostly hampered by insufficient potency, limited target selectivity or lack of bioactivity translation from the isolated enzyme to the parasite in cellular environments. In this study, we report the design of , a 1,2,3-triazole-based targeted covalent inhibitor with nanomolar potency (IC = 28 nM) and null inhibition of human cathepsin L.
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