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Serotonin receptor 5-HT7 modulates inflammatory-associated functions of macrophages.
Cell Mol Life Sci
January 2025
Cellular Neurophysiology, Hannover Medical School, Hannover, Germany.
The hormone and neurotransmitter serotonin regulates numerous physiological functions within the central nervous system and in the periphery upon binding to specific receptors. In the periphery, the serotonin receptor 7 (5-HT7R) is expressed on different immune cells including monocytes and macrophages. To investigate the impact of 5-HT7R-mediated signaling on macrophage properties, we used human THP-1 cells and differentiated them into pro-inflammatory M1- and anti-inflammatory M2-like macrophages.
View Article and Find Full Text PDFS-layers: from a serendipitous discovery to a toolkit for nanobiotechnology.
Q Rev Biophys
January 2025
Institute of Synthetic Bioarchitectures, Department of Bionanosciences, University of Natural Resources and Life Sciences, Vienna, Austria.
Prokaryotic microorganisms, comprising and , exhibit a fascinating diversity of cell envelope structures reflecting their adaptations that contribute to their resilience and survival in diverse environments. Among these adaptations, surface layers (S-layers) composed of monomolecular protein or glycoprotein lattices are one of the most observed envelope components. They are the most abundant cellular proteins and represent the simplest biological membranes that have developed during evolution.
View Article and Find Full Text PDFKir4.1 and Aqp4 Contribution to Schisis Cystic Water Accumulation and Clearance in the Rs1 Exon-1 Del XLRS Rat Model.
Genes (Basel)
December 2024
Department of Ophthalmology, Eye Center, UC Davis School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Background/objective: The Rs1 exon-1-del rat (Rs1KO) XLRS model shows normal retinal development until postnatal day 12 (P12) when small cystic spaces start to form in the inner nuclear layer. These spaces enlarge rapidly, peak at P15, and then collapse by P19.
Methods: We explored the possible involvement of Kir4.
Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.
ACS Omega
December 2024
Advanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, U.K.
Article Synopsis
- The study develops high yttrium-content phosphate-based glass-ceramic microspheres for use in bone cancer radiotherapy, showcasing their production through flame spheroidization and resulting in a narrow size distribution (45-125 μm).
- Energy dispersive X-ray (EDX) analysis indicates an increase in yttrium content in the microspheres with higher yttrium oxide ratios, while showing a uniform distribution and a decrease in phosphate, calcium, and magnesium levels.
- In vitro tests reveal that these microspheres exhibit good cytocompatibility, with enhanced cellular responses compared to earlier P40 glass microspheres, highlighting their potential as biomaterials for cancer treatment.
Simultaneous Isolation and Preparation of Extracellular Vesicles by Circular Multicavity Electrophoresis.
Anal Chem
January 2025
Interdisciplinary, Molecular Biology of Biological Function, Changbai Mountain Key Laboratory of Natural Medicine of Ministry of Education, Yanbian University, Yanji 133000, China.
Extracellular vesicles (EVs) play a crucial role in diagnosis and treatment, yet obtaining highly purified EVs from complex biological samples is often hindered by nanoscale contaminants. In this work, considering the charge-to-size characteristics of EVs, a circular multicavity electrophoresis (CME) with gradient pore size distribution was constructed in the gradient electric field to realize the isolation and preparation of EVs. By the gradient gel sieving effect, small cell debris, EVs, and proteins in biological samples were gradually separated.
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