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Raised body mass index and reduced muscle bulk reduces the incidence of Popeye's deformity post tenotomy of long head of biceps brachii.
J ISAKOS
October 2024
Department of Orthopaedic Surgery, Singapore General Hospital, 20 College Road, Academia Building Level 4, 169856, Singapore.
Article Synopsis
- The study investigates factors leading to the development of Popeye's deformity, a common complication (13%-70% incidence) after long head of the biceps tendon (LHBT) tenotomy, to improve patient selection for surgery.
- 91 patients undergoing rotator cuff repairs and LHBT tenotomy were analyzed based on demographics, physical attributes, and postoperative satisfaction through various pain and shoulder function scores at 6 and 24 months post-operation.
- Results showed a 58.9% incidence of Popeye's sign, with lower body mass index (BMI) and higher biceps to wrist circumference ratios linked to deformity, but it did not impact overall clinical outcomes or patient satisfaction after 24 months.
Concomitant Botulinum Toxin Injections for Neurogenic Detrusor Overactivity and Spasticity-A Retrospective Analysis of Practice and Safety.
Toxins (Basel)
May 2024
Spinal Unit, Department of Physical and Rehabilitation Medicine, Raymond Poincaré Teaching Hospital, APHP Paris Saclay, 92380 Garches, France.
Article Synopsis
- This study explored the safety and effectiveness of simultaneous botulinum toxin injections (BTIs) used to treat both spasticity and neurogenic detrusor overactivity incontinence (NDOI) in patients with spinal cord injuries and multiple sclerosis.
- Researchers identified 72 patients over five years who received both types of injections within one month, revealing a majority were male (69%) and mostly had spinal cord injuries (76%).
- The analysis showed 95% of injections occurred within 72 hours, with very few adverse symptoms reported, suggesting that simultaneous BTIs are safe when adhering to established dosage guidelines.
All-suture anchor size and drill angle influence load to failure in a porcine model of subpectoral biceps tenodesis, a biomechanical study.
BMC Musculoskelet Disord
May 2024
Gelenkpunkt - Sports and Joint Surgery, Innsbruck, Austria.
Article Synopsis
- This study examines the biomechanical properties of three all-suture anchors used for biceps tenodesis, specifically looking at their load-to-failure characteristics and optimal insertion angles in porcine humeri models.
- The findings indicate that the 2.6 FiberTak® anchor had the highest load-to-failure at a 90° angle compared to the 1.9 and 1.6 FiberTak® anchors, with significant differences observed across insertion angles.
- Overall, while all anchors proved effective, the study suggests that using a 90° insertion angle maximizes fixation strength, and the 2.6 FiberTak® is particularly promising due to its unique failure mode.
HDACi vorinostat protects muscle from degeneration after acute rotator cuff injury in mice.
Bone Joint Res
April 2024
Technological Innovation Division, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV) and IdiSNA, Pamplona, Spain.
Article Synopsis
- Rotator cuff injuries can cause serious damage to muscles and tendons, making it hard for them to heal properly.
- Scientists tested a drug called vorinostat to see if it could help prevent muscle damage and encourage muscle repair in mice with rotator cuff injuries.
- The results showed that vorinostat helped stop harmful changes in muscle cells and protected the muscle from getting worse after an injury.
Lack of vitamin D signalling in mesenchymal progenitors causes fatty infiltration in muscle.
J Cachexia Sarcopenia Muscle
June 2024
Center for Frailty and Locomotive Syndrome, National Center for Geriatrics and Gerontology, Obu, Japan.
Background: Recent studies have indicated the importance of muscle quality in addition to muscle quantity in sarcopenia pathophysiology. Intramuscular adipose tissue (IMAT), which originates from mesenchymal progenitors (MPs) in adult skeletal muscle, is a key factor affecting muscle quality in older adults, suggesting that controlling IMAT formation is a promising therapeutic strategy for sarcopenia. However, the molecular mechanism underlying IMAT formation in older adults has not been clarified.
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