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Zinc-Biofortified Rice Improves Growth in Zinc-Deficient Rats.
Biol Trace Elem Res
December 2024
ICMR-National Institute of Nutrition, Hyderabad, 500007, Telangana, India.
Biofortification of staple food crops with zinc (Zn) is considered a sustainable strategy to prevent deficiency, but evidence on their health impact is awaited. The weaning Wistar/Kyoto male rats were fed on a Zn-deficient diet (ZDD, < 0.1 ppm) for 4 weeks followed by repletion (pair feeding) with control rice diet without (CRD; 5.
View Article and Find Full Text PDFInvestigation of Zur-regulated metal transport systems reveals an unexpected role of pyochelin in zinc homeostasis.
mBio
October 2024
Department of Biology, Tor Vergata University of Rome, Rome, Italy.
Unlabelled: Limiting the availability of transition metals at infection sites serves as a critical defense mechanism employed by the innate immune system to combat microbial infections. exhibits a remarkable ability to thrive in zinc-deficient environments, facilitated by intricate cellular responses governed by numerous genes regulated by the zinc-responsive transcription factor Zur. Many of these genes have unknown functions, including those within the predicted and operons.
View Article and Find Full Text PDFZinc Deficiency and the Severity of Pneumonia in Vietnamese Children: A Hospital-Based Study.
Cureus
July 2024
Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City, VNM.
Background Pneumonia is a critical global health concern that often results in severe complications and fatalities, especially among young children. Zinc plays a crucial role in immune function and maintaining respiratory epithelial integrity. Despite its importance, data on the prevalence of zinc deficiency and its impact on pneumonia severity in Vietnamese children are limited.
View Article and Find Full Text PDFZinc Deficiency Causes Glomerulosclerosis and Renal Interstitial Fibrosis Through Oxidative Stress and Increased Lactate Metabolism in Rats.
Biol Trace Elem Res
July 2024
Department of Nephrology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Article Synopsis
- Chronic kidney disease (CKD) is a serious health condition where the kidneys get damaged over time, and it's linked to a lack of zinc in the body.
- Researchers are studying how low zinc levels can cause kidney problems by looking at how certain pathways in the body are affected and how they lead to kidney damage.
- Their experiments on rats show that a zinc-deficient diet can worsen kidney function and lead to higher levels of substances in urine and blood that indicate kidney stress.
Marginal Zinc Deficiency Aggravated Intestinal Barrier Dysfunction and Inflammation through ETEC Virulence Factors in a Mouse Model of Diarrhea.
Vet Sci
September 2022
College of Biology Engineering, Henan University of Technology, Zhengzhou 450001, China.
Zinc is both essential and inhibitory for the pathogenesis of enterotoxigenic (ETEC). However, the accurate effects and underlying mechanism of marginal zinc deficiency on ETEC infection are not fully understood. Here, a marginal zinc-deficient mouse model was established by feeding mice with a marginal zinc-deficient diet, and ETEC k88 was further administrated to mice after antibiotic disruption of the normal microbiota.
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