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Platelet ultrastructural changes stored at room temperature versus cold storage observed by electron microscopy and structured illumination microscopy.
Exp Hematol
January 2025
Department of Transfusion Medicine, Shaanxi Provincial Peoples Hospital, Xi'an, China. Electronic address:
Our study seeks to provide a theoretical foundation for the clinical use of cold-stored platelets (CSPs) by interpreting ultrastructural images and quantitatively analyzing structural changes. CSPs, room temperature-stored platelets (RTPs), and delayed CSPs (delayed-CSPs) were continuously observed using scanning electron microscopy and transmission electron microscopy at eight time points. Super-resolution fluorescence microscopy was employed to observe changes in platelet microtubules and mitochondrial structure and function, whereas platelet counts, metabolism, and relevant functional indicators were measured concurrently.
View Article and Find Full Text PDFMorphological and cytochemical characterization of the peripheral blood cells in .
Heliyon
September 2024
Lab of Pathology and Immunology of Aquatic Animals, Jiangsu Ocean University, Lianyungang, 222005, China.
The flounder () is a highly nutritious, cultured bony fish with a high economic value. The health of the fish is closely related to its blood cells, which are critical for oxygen transport, natural defense, and immunity. The microstructures, classification, counting and size of peripheral blood cells in .
View Article and Find Full Text PDFSkin Telocytes Could Fundament the Cellular Mechanisms of Wound Healing in Platelet-Rich Plasma Administration.
Cells
August 2024
Department of Cellular and Molecular Biology and Histology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
For more than 40 years, autologous platelet concentrates have been used in clinical medicine. Since the first formula used, namely platelet-rich plasma (PRP), other platelet concentrates have been experimented with, including platelet-rich fibrin and concentrated growth factor. Platelet concentrates have three standard characteristics: they act as scaffolds, they serve as a source of growth factors and cytokines, and they contain live cells.
View Article and Find Full Text PDFA Xenograft Model of Kaposiform Hemangioendothelioma in Nude Mice Recapitulates Kasabach-Merritt Phenomenon.
Ann Vasc Surg
November 2024
Department of Plastic Surgery, Nanjing Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu, China; Department of Plastic Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China. Electronic address:
Article Synopsis
- The Kasabach-Merritt phenomenon (KMP) is linked to vascular tumors and involves low platelet counts and blood clotting issues; its cause and treatment are not well understood.
- The study aimed to create an animal model of KMP by transplanting a piece of a Kaposiform hemangioendothelioma (KHE) tumor into nude mice, monitoring platelet levels and tumor characteristics over 16 weeks.
- Results showed a significant drop in platelet counts shortly after transplantation, with a gradual recovery over time, and tumor analysis indicated changes in structure and composition, confirming the model's relevance for future KMP research and treatment development.
Fibrin Network and Platelets Densities in Platelet-Rich Fibrin (PRF) Membranes Produced from Plastic Tubes Without Additives: A New Approach to PRF Clinical Use.
J Maxillofac Oral Surg
June 2024
Department of Cell Biology, Histology and Embryology, Biomedical Science Institute, Federal University of Uberlandia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama, Uberlândia, Minas Gerais 38.400-902 Brazil.
Background/purpose: The present study aimed to investigate plastic tubes without additives as alternatives to glass and silica-coated plastic tubes, in the production of PRF membranes.
Materials And Methods: Nine blood samples were collected from eight volunteers ( = 8) separated into three groups, according to tube material: glass, silica-coated plastic, and plastic without additives. In each group, the samples were centrifuged using different relative centrifugation forces: L-PRF (700 g/12 min), A-PRF (200 g/14 min), and A-PRF + (200 g/8 min).
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