Australian native trees of the genus Duboisia contain high concentrations of atropine-like alkaloids, especially hyoscine. Occupational exposure to the dried plant material results in two clinical syndromes: "cork-eye", and being "corked up". Plant abuse, as an intoxicant and hallucinogen, also results in the "corked up" syndrome. This paper presents four cases of the Duboisia syndrome. Central effects and peripheral anticholinergic effects are encountered in both occupational and accidental field exposure. The particular susceptibility of children, and management of the Duboisia poisoning syndrome are discussed.
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http://dx.doi.org/10.5694/j.1326-5377.1981.tb101037.x | DOI Listing |
Biochemistry
January 2023
Department of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch Straße 10, 35043 Marburg, Germany.
Mesaconyl-CoA transferase (Mct) is one of the key enzymes of the 3-hydroxypropionate (3HP) bi-cycle for autotrophic CO fixation. Mct is a family III/Frc family CoA transferase that catalyzes an unprecedented intra-molecular CoA transfer from the C1-carboxyl group to the C4-carboxyl group of mesaconate at catalytic efficiencies >10 M s. Here, we show that the reaction of Mct proceeds without any significant release of free CoA or the transfer to external acceptor acids.
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