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Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant.
Virol J
January 2025
Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are ideal targets for therapeutic vaccines. We have previously developed an HPV 16 DNA vaccine encoding a modified E7/HSP70 (mE7/HSP70) fusion protein, which demonstrated significant antitumor effects in murine models.
View Article and Find Full Text PDFAn integrative analysis reveals cancer risk associated with artificial sweeteners.
J Transl Med
January 2025
Medical College of YiChun University, Xuefu Road No 576, Yichun, 336000, Jiangxi, People's Republic of China.
Background: Artificial sweeteners (AS) have been widely utilized in the food, beverage, and pharmaceutical industries for decades. While numerous publications have suggested a potential link between AS and diseases, particularly cancer, controversy still surrounds this issue. This study aims to investigate the association between AS consumption and cancer risk.
View Article and Find Full Text PDFEarly childhood caries risk prediction using machine learning approaches in Bangladesh.
BMC Oral Health
January 2025
Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Bergen, Norway.
Background: In the last years, artificial intelligence (AI) has contributed to improving healthcare including dentistry. The objective of this study was to develop a machine learning (ML) model for early childhood caries (ECC) prediction by identifying crucial health behaviours within mother-child pairs.
Methods: For the analysis, we utilized a representative sample of 724 mothers with children under six years in Bangladesh.
Background: Elderly individuals living alone represent a vulnerable group with limited family support, making them more susceptible to mental health issues such as depression and anxiety. This study aims to construct a network model of depression and anxiety symptoms among older adults living alone, exploring the correlations and centrality of different symptoms. The goal is to identify core and bridging symptoms to inform clinical interventions.
View Article and Find Full Text PDFDoes famine during the fetal period increase the degree of disability of the elderly?-An empirical study based on data from China.
BMC Public Health
January 2025
School of Public Administration, Zhongnan University of Economics and Law, Wuhan, China.
Background: People who have experienced the Chinese Great Famine (1959-1961) in their fetal period are getting old. It is particularly important for China's response to the ageing of this cohort to study the impact of the Holodomor on disability.
Method: This paper presents an empirical analysis that utilizes the survey data from the 2018 China Health and Retirement Longitudinal Study (CHARLS), employing a cohort Difference-in-Differences (DID) modeling approach.
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