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Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons.
Proc Natl Acad Sci U S A
January 2025
Department of Neuroscience, Farber Institute for Neuroscience and Jefferson Synaptic Biology Center, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
Use-dependent spike broadening (UDSB) results from inactivation of the voltage-gated K (Kv) channels that regulate the repolarization of the action potential. However, the specific signaling and molecular processes that modulate UDSB have remained elusive. Here, we applied an adeno-associated viral vector approach and dynamic clamping to conclusively demonstrate how multisite phosphorylation of the N-terminal inactivation domain (NTID) of the Kv3.
View Article and Find Full Text PDFAutologous Fascia Nerve Wrap in a Rodent Primary Epineurial Repair Model and Preliminary Case Series.
Plast Reconstr Surg
December 2024
Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Background: Nerve wraps composed of various autologous and bioengineered materials have been used to bolster nerve repair sites. In this study, we describe the novel use of autologous fascia nerve wraps (AFNW) as an adjunct to epineurial repair and evaluate their effect on inflammatory cytokine expression, intraneural collagen deposition and end-organ reinnervation in rats and use of AFNW in a patient case series.
Methods: Lewis rats received sciatic transection with repair either with or without AFNW, sciatic-to-common peroneal nerve transfer with or without AFNW, or sham surgery (n=14/group).
Deep brain stimulation of the medial forebrain bundle promotes the extinction of active avoidance and is associated with mossy fibber sprouting in the hippocampus.
Behav Brain Res
December 2024
Departament de Biologia, Universitat de Girona, Girona, Spain. Electronic address:
Background: Post-traumatic stress disorder (PTSD) causes intrusive symptoms and avoidance behaviours due to dysregulation in various brain regions, including the hippocampus. Deep brain stimulation (DBS) shows promise for refractory PTSD cases. In rodents, DBS improves fear extinction and reduces anxiety-like behaviours, but its effects on active-avoidance extinction remain unexplored.
View Article and Find Full Text PDFAmeliorative effects of Ganoderma lucidum (Reishi) on testicular tissue of rats exposed to bisphenol A.
Pol J Vet Sci
September 2024
Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Fırat University, 23119, Elazığ, Turkey.
Bisphenol A (BPA), an endocrine disrupting chemical, is an environmental toxicant widely used in the production of polycarbonate plastics, epoxy resins and paints. Ganoderma lucidum (GDL) is a plant with biological activities widely used in Chinese medicine. The present study aims to determine the effects of GDL against testicular dysfunction in rats exposed to BPA.
View Article and Find Full Text PDFOptimization of Existing RNA Visualization Methods Reveals Novel Dendritic mRNA Dynamics.
Front Biosci (Landmark Ed)
December 2024
Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA.
Background: Spatial-temporal control of mRNA translation in dendrites is important for synaptic plasticity. In response to pre-synaptic stimuli, local mRNA translation can be rapidly triggered near stimulated synapses to supply the necessary proteins for synapse maturation or elimination, and 3' untranslated regions (UTRs) are responsible for proper localization of mRNAs in dendrites. Although is a robust technique for analyzing RNA localization in fixed neurons, live-cell imaging of RNA dynamics remains challenging.
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